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Perivascular Stem/Progenitor Cells

Perivascular Stem Cells Inhibit Osteoclasts

Human perivascular progenitor cells reduce osteoclast formation, thereby preventing bone graft resorption and yielding better outcomes in a preclinical xenograft model 

Novel Study Identifies Cortical Bone Perivascular Osteoprogenitors

A refined cell identification strategy identifies a novel population of non-osteocytic perivascular osteoprogenitors with the ability to regenerate cortical bone tissue

Transcriptional Analysis of Fetal Mesangioblasts May Boost Muscle Regeneration Strategies

Correlations between transcriptomic profiles and myogenic differentiation potential may improve mesoangioblast-based skeletal and cardiac muscle regeneration approaches

PDGFRα-Expressing Perivascular Progenitors

Researchers led by Aaron W. James (Johns Hopkins University, Baltimore, MD, USA) recently discovered that platelet‐derived growth factor-alpha (PDGFRα) expression marks perivascular subpopulations of adipose stroma that possess a heightened tendency to take part in osteoblastogenesis. As a possible pathologic correlate of these observations, Wang et al.

HDAC7 Peptide Boosts Vascular Regeneration

Histone deacetylase 7 (HDAC7) plays a pivotal role in the maintenance of endothelial integrity, and while we know that short open reading frames (sORFs) exist within the 5′ terminal non‐coding area of Hdac7 mRNA, it remains unclear whether these sORFs contribute to HADC7 function.

CD10-positive Osteogenic Adventitial Precursors

Perivascular adventitial cells include multipotent progenitor cells that give rise to mesenchymal stem/progenitor cells in culture.

ESC-Derived Perivascular Progenitor Cells: A New Treatment for Diabetes-associated Vision Loss

Vision loss in diabetes could be prevented through the application of embryonic stem cell-derived cells

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