Perivascular Stem/Progenitor Cells

Human perivascular progenitor cells reduce osteoclast formation, thereby preventing bone graft resorption and yielding better outcomes in a preclinical xenograft model 

A refined cell identification strategy identifies a novel population of non-osteocytic perivascular osteoprogenitors with the ability to regenerate cortical bone tissue

Correlations between transcriptomic profiles and myogenic differentiation potential may improve mesoangioblast-based skeletal and cardiac muscle regeneration approaches

Researchers led by Aaron W. James (Johns Hopkins University, Baltimore, MD, USA) recently discovered that platelet‐derived growth factor-alpha (PDGFRα) expression marks perivascular subpopulations of adipose stroma that possess a heightened tendency to take part in osteoblastogenesis. As a possible pathologic correlate of these observations, Wang et al.

Histone deacetylase 7 (HDAC7) plays a pivotal role in the maintenance of endothelial integrity, and while we know that short open reading frames (sORFs) exist within the 5′ terminal non‐coding area of Hdac7 mRNA, it remains unclear whether these sORFs contribute to HADC7 function.

Perivascular adventitial cells include multipotent progenitor cells that give rise to mesenchymal stem/progenitor cells in culture.

Vision loss in diabetes could be prevented through the application of embryonic stem cell-derived cells