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Mammalian Regeneration

Novel Cell Conversion Approach to Neural Regeneration and Hearing Loss Reversal

Lin28-mediated conversion of inner-ear glia into neurons represents a new approach to the replacement of lost/damaged auditory nerves and the reversal of hearing loss

Transcriptional Study Paves the Way for Novel Heart Regeneration Strategy

New research finds that overexpression of Myc and a transcription elongation factor promotes cardiomyocyte proliferation in the adult mouse heart

CRISPR-approach May Decipher Axolotl Limb Regeneration

CRISPR-mediated negative selection screen in regenerating haploid axolotl limbs uncovers candidate genes crucial to the limb regeneration process

Tissue Repair Brakes - A Review

The state of differentiation of a given cell is not carved in stone; cell identity can be modulated by inhibitory signals from the cellular environment. Therefore, cell identity maintenance represents an active process of inhibition of a natural trend to change, and not an intrinsic or passive state of differentiation.

The Epigenetic Balancing Act of Liver Regeneration

Repressive epigenetic marks divert from proregenerative gene promoters to compensate for the loss of transposon silencing following hepatectomy in mice

Inducing Neurophysiological Recovery of the Post-mortem Mammalian Brain

A novel approach restores and maintains microcirculation and cellular viability in the brain of a large animal model after a prolonged post-mortem interval

Is an Extracellular Matrix Component the Key to Adult Cardiac Regeneration?

A new study finds that the extracellular matrix component Agrin promotes adult cardiac regeneration in a mouse model of heart disease

New Study Describes how Macrophages Mediate Tissue Remodeling

A new study indicates that macrophages promote contact between distant non-immune color-bearing cells to control tissue remodeling

How a Little Activity can Boost CNS Regeneration

A new study shows that stimulating neuronal activity may lead to enhanced central nervous system regeneration

TREEs – Tissue Regeneration Branches-out into Mammals?

Researchers studying Zebrafish discover a genetic element which controls regenerative responses and show how this may be introduced into mammalian system to boost regeneration.

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