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Intestinal Stem/Progenitor Cells

Increased Wnt/β-catenin Signaling Allows Overcrowded Stem Cells to Self-renew

Cellular physical properties can promote intestinal stem cell self-renewal by inducing intracellular crowding and maintaining an elevated response to Wnt ligands

Treating ETEC by Restoring Wnt‐dependent ISCs

New evidence supports the restoration of Wnt‐dependent ISCs as a promising therapeutic target for ETEC treatment

Extracellular Vesicles in The ISC Niche

While we understand the critical nature of intestinal stem cells (ISC)-stem cell niche interactions in maintaining tissue integrity, we still lack clarity regarding the transmission of ISC niche factors.

Regenerating the Aged and Damaged Intestine by Saying “No” to Notum

Researchers highlight Notum inhibition as a means to enhance the regeneration of aged ISCs and promote intestinal recovery from chemotherapy-induced damage

Mitigating ARS in the Mouse Gut

Exposure to lethal doses of ionizing radiation manifests as acute radiation syndrome (ARS), with the extent of radiation damage to the hematopoietic and gastrointestinal (GI) systems codetermining the acute survival of the exposed individual.

How Short-term Fasting Affects Intestinal Stem Cell Function during Aging

Researchers discover than short-term fasting induces intestinal regenerative effects via increases in fatty acid oxidation in intestinal stem cells

Calorie Restriction Promotes Intestinal Regeneration by Reserve Intestinal Stem Cells

A new study identifies mTORC1 activity in reserve intestinal stem cells mediates epithelial regeneration in calorie restricted mice

Deregulated Intestinal Stem and Progenitor Cells - Linking Obesity to Cancer

A new study demonstrates how dietary fat can promote tumorigenesis though modulating signaling in intestinal stem/progenitor cells

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