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ESCs/iPSCs

Immunogenicity Of iPSC-derived Myogenic Cells

Analysis of humanized mouse models provided evidence that human immune cell infiltration in skeletal muscle should not be used alone to predict immunogenicity

iPSC for Neurodevelopmental Disorders

researchers review current knowledge regarding iPSC models for schizophrenia and autism spectrum disorders with an emphasis on their discrimination.

YAP Regulates Cartilage Formation from iPSCs

A laminin-based culture substrate causes poor chondrogenesis from hiPSCs, while the inactivation of YAP promotes a round cell morphology and improves cartilage formation

Donor Genetic Traits Impact Stem Cell Heterogeneity

A new review discusses the roles played by donor genetic traits in the functional heterogeneity of stem cells and their implications for regenerative medicine and therapy

Cp40 Reverses Pathology in AMD-RPE

The modulation of the complement system may represent a useful therapeutic approach for AMD cases associated with complement dysregulation.

Adjuvant Therapy for Cardiac Cell Transplantation

sEHIs results in a significant increase in the retention of transplanted cells and an improvement in cardiac function 

Accelerated Neural Differentiation of hPSCs

A new study removes a historical bottleneck that has hindered improvement to the control and speed of generating neural cells from hPSCs.

Perspective on Cardiac Application Of hPSCs

The ability to generate multiple cardiac cell types from human pluripotent stem cells will provide researchers with the means to evaluate their application in the repair of damaged myocardium.

Preclinical Safety Study Provides Support for hESC-RPE as a Vison Loss Treatment

Wide-raging analyses support the safety of human embryonic stem cell‐derived retinal pigment epithelium generated by an optimized in vitro differentiation methodology

Non-invasive Tracking of iPSC-Cardiomyocytes

A proof‐of‐principle study reports on the sensitive in vivo tracking of iPSC‐CMs in a clinically relevant model of myocardial infarction

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