ESCs/iPSCs

A new Cell study highlights the importance of two generally unappreciated mechanisms, splicing and protein synthesis, to the pluripotent state and the developing embryo

A new study from the Knoepfler laboratory reveals EBP1 as a major cofactor that influences the transcriptional activity of DPPA4 in pluripotent cells

A new study takes the field further towards the industrial-scale culture and safe and cost-effective clinical application of human pluripotent stem cells

Researchers studying the molecular mechanisms that control mitochondrial dynamics in pluripotent cells discover a role for the apoptosis-related protein MCL-1

Researchers demonstrate how CRISPR/Cas9-mediated exon skipping, or myoediting, may rescue dystrophin function in a majority of Duchenne muscular dystrophy patients

A new study identifies a long non-coding RNA as an important barrier impeding the reprogramming of cells derived from old patients

A new study suggests that DNA methylation analysis of select gene promoters can identify the optimal pluripotent stem cell for bone repair strategies

For the first time, researchers describe the formation of entirely hPSC-derived 3D muscle tissues that survive, vascularize, and maintain function following transplantation

Using an efficient and synchronous reprogramming system, researchers describe the dynamic alterations to genome topology, chromatin states, and gene expression

New research from the University of North Carolina establishes a link between rapid origin licensing and the maintenance of stem cell pluripotency