ESCs/iPSCs

Researchers report how a large intergenic non-coding RNA inhibits the early stage of mouse embryonic stem cell differentiation by regulating LIF/STAT3 signaling

While recent studies have demonstrated the generation of human pluripotent stem cell (PSC)-derived midbrain organoids that display structural and functional features of the midbrain, multiple issues currently hinder clinical translation.

Chemically-induced pluripotent stem cells generated from granulosa cells can differentiate into primordial-germ-cell-like cells and form oocytes that produce fertile mice

Modeling human neurodevelopmental disease using stem cell biology techniques requires significant expertise to allow for the discovery of cell phenotypes.

A new STEM CELLS Translational Medicine article led by Naoya Uchida (National Insti

The liver is an essential organ in the body that performs crucial functions such as metabolism, and recently, researchers have invested enormous resources to generate liver cells from induced pluripotent stem cells and to develop robust three-dimensional liver organoids that faithfully resemble the liver. Now, a team led by Setjie W.

Nicotinamide adenine dinucleotide (NAD+) induces an intermediate state of naivety in human embryonic stem cells (hESCs) characterized by a shift from glycolytic to oxidative metabolism, increased self‐renewal, and epigenetic alterations. Conversely, inhibition of the malate aspartate shuttle (MAS), which recycles NAD+, causes a dramatic loss of oxidative metabolism and pluripotency marker expression.

The generation of induced pluripotent stem cell employing the lentiviral transduction of Sox2, Klf4, and Myc only generates cells with improved developmental potential

A new organoid generation protocol may provide the means to generate powerful in vitro models to study therapeutic approaches to a range of liver diseases and disorders

Alteration of fibroblast composition and increased inflammatory cytokine secretion during aging drives reprogramming variability in vitro and wound healing rate in vivo