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Housekeeping Matters: How Splicing and Protein Synthesis Regulate Pluripotency and Development

A new Cell study highlights the importance of two generally unappreciated mechanisms, splicing and protein synthesis, to the pluripotent state and the developing embryo

DPPA4 Function in Pluripotent Stem Cells: EBP1 Lends a Hand

A new study from the Knoepfler laboratory reveals EBP1 as a major cofactor that influences the transcriptional activity of DPPA4 in pluripotent cells

Another Step towards the Fully Synthetic Culture of Human Pluripotent Stem Cells

A new study takes the field further towards the industrial-scale culture and safe and cost-effective clinical application of human pluripotent stem cells

Laying Bare the Molecular Mechanisms behind Mitochondrial Dynamics in Pluripotent Stem Cells

Researchers studying the molecular mechanisms that control mitochondrial dynamics in pluripotent cells discover a role for the apoptosis-related protein MCL-1

Myoediting: Towards a CRISPR/Cas9-based Treatment for DMD-associated Dilated Cardiomyopathy

Researchers demonstrate how CRISPR/Cas9-mediated exon skipping, or myoediting, may rescue dystrophin function in a majority of Duchenne muscular dystrophy patients

Zeb2-NAT lncRNA: Breaking Down Age-associated Reprogramming Barriers

A new study identifies a long non-coding RNA as an important barrier impeding the reprogramming of cells derived from old patients

Osteoblast Differentiation Study Recommends Choosing your Stem Cell Wisely!

A new study suggests that DNA methylation analysis of select gene promoters can identify the optimal pluripotent stem cell for bone repair strategies

In vitro Generation of hPSC-derived Functional Skeletal Muscle Tissue

For the first time, researchers describe the formation of entirely hPSC-derived 3D muscle tissues that survive, vascularize, and maintain function following transplantation

Correlating Genome Topology and Gene Regulation during Reprogramming

Using an efficient and synchronous reprogramming system, researchers describe the dynamic alterations to genome topology, chromatin states, and gene expression

Stem Cells: License to be Pluripotent!

New research from the University of North Carolina establishes a link between rapid origin licensing and the maintenance of stem cell pluripotency


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