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ESCs/iPSCs

Can Tissue Inhibitor of Metalloproteinases Ensure the Safety of PSC-derived Therapies?

Researchers demonstrate that tissue inhibitor of metalloproteinase proteins may inhibit PSC‐derived teratoma formation through cell cycle arrest and increased apoptosis

Subtype‐Specific Cardiomyocytes for Precision Medicine

A new review article from the laboratory of Ming‐Tao Zhao (Nationwide Children's Hospital/Ohio State University College of

Subtype Separation of iPSC-derived Cardiomyocytes May Foster Safer Therapies

Researchers describe a novel strategy for the isolation of pure populations of subtype-specific cardiomyocytes from differentiating cultures of induced pluripotent stem cells

Propagation of Human Prostate Tissue from iPSCs

Culturing cells from prostate cancer biopsies to study mechanisms of disease and discover novel treatments suffers from many difficulties; however, a new study from the laboratory of Rakesh Heer

Increased pH Limits Formation of WPB in hiPSC-ECs

Researchers from the lab of Ton J.

Cyst Epithelial-derived iPSCs from ADPKD Patients

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, leads to kidney failure in most patients. While mutations in the Polycystin 1 (PKD1) gene cause 85% of cases, we do not fully understand how dysregulation of PKD1 leads to cyst formation on a molecular level.

OSKM Selectively Target Leukemia

The four transcription factors that make up the Yamanaka “cocktail” (Oct4, Sox2, Klf4, and Myc, or OSKM) are well known for their capacity to reprogram somatic cells into induced pluripotent stem cells (iPSCs).

iPSC-Derived Endothelial Cells to Treat Hemophilia

A recent STEM CELLS Translational Medicine article from the labs of

Increasing Dopamine Levels in Induced Ventral Midbrain Cells

Making high‐quality dopamine‐producing cells for basic studies or small molecule screening remains critical to the development of novel therapeutics for ventral midbrain disorders. However, many ventral midbrain assays suffer from low signal to noise ratio thanks to low levels of dopamine and tyrosine hydroxylase, the rate‐limiting enzyme for dopamine synthesis.

Patient-specific iPSCs Aid the Development of New Age-related Macular Degeneration Model

Researchers report on a new age‐related macular degeneration model that more faithfully mimics the interaction of RPE and Bruch's membrane under disease conditions

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