ESCs/iPSCs

Researchers demonstrate that tissue inhibitor of metalloproteinase proteins may inhibit PSC‐derived teratoma formation through cell cycle arrest and increased apoptosis

A new review article from the laboratory of Ming‐Tao Zhao (Nationwide Children's Hospital/Ohio State University College of

Researchers describe a novel strategy for the isolation of pure populations of subtype-specific cardiomyocytes from differentiating cultures of induced pluripotent stem cells

Culturing cells from prostate cancer biopsies to study mechanisms of disease and discover novel treatments suffers from many difficulties; however, a new study from the laboratory of Rakesh Heer

Researchers from the lab of Ton J.

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, leads to kidney failure in most patients. While mutations in the Polycystin 1 (PKD1) gene cause 85% of cases, we do not fully understand how dysregulation of PKD1 leads to cyst formation on a molecular level.

The four transcription factors that make up the Yamanaka “cocktail” (Oct4, Sox2, Klf4, and Myc, or OSKM) are well known for their capacity to reprogram somatic cells into induced pluripotent stem cells (iPSCs).

A recent STEM CELLS Translational Medicine article from the labs of

Making high‐quality dopamine‐producing cells for basic studies or small molecule screening remains critical to the development of novel therapeutics for ventral midbrain disorders. However, many ventral midbrain assays suffer from low signal to noise ratio thanks to low levels of dopamine and tyrosine hydroxylase, the rate‐limiting enzyme for dopamine synthesis.

Researchers report on a new age‐related macular degeneration model that more faithfully mimics the interaction of RPE and Bruch's membrane under disease conditions