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Modeling Aortic Diseases Using iPSCs

A review summarizes in vitro models used in aortic disease research and provides guidance for the development of advanced models using iPSCs

Chromatin Accessibility in Canine Reprogramming

New research identifies differences in the global chromatin landscape that occur during the cellular reprogramming of canine cells

Ischemic Disease Therapy Using Human iPSCs

iPSC‐derived smooth muscle cells enhance iPSC‐derived endothelial cells' therapeutic efficacy in peripheral artery disease

hPSC-derived Beta Cells with Enhanced Function

Adding islet-associated environmental cues could represent a promising route to enhance the function of hPSC‐derived beta cells

New Advance Hastens the Production of Neural Cells from Human Pluripotent Stem Cells

A new study reports the efficient and rapid differentiation of human PSCs into a neural precursor population with early intermediate ectodermal characteristics

Drug Screening for Nakajo-Nishimura Syndrome

HDAC inhibitor identified as a Nakajo‐Nishimura syndrome treatment by screening using PSC‐derived monocytic cell lines

CAG Promoter Activity and Reprogramming

A novel and simple methodology an identify and enrich somatic cells correctly undergoing reprogramming into induced pluripotent stem cells

Exploring Human Stem Cell Therapies for Cerebral Cortex Disorders in Human Organotypic Culture

Functional engraftment of human iPSC-derived neurons into a human adult host neural network may boost the clinical translation of novel cerebral cortex treatments

Eradicating PSCs with DHODH Inhibitors

An inhibitor of dihydroorotate dehydrogenase specifically induces elevated levels of cytotoxicity in mouse PSCs

Towards the Three-dimensional Bioprinting of a Human Heart

Researchers use induced pluripotent stem cells grown and differentiated within an extracellular matrix bioink to develop a chambered muscle pump


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