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Towards the Development of Xenogeneic Organs with Donor-derived Endothelium

Researchers explore embryo complementation with human induced pluripotent stem cells to rescue ETV2-mutant embryos and generate donor-cell derived hematoendothelium

FGF1‐RUNX2 Signaling in Neural Crest Osteoprogenitors

Given that the human skeleton arises from different embryonic origins, modeling early bone development with human pluripotent stem cells may benefit from a method of lineage‐specific derivation.

hiPSC Serial Expansion in Vertical-wheel Bioreactors

A recent STEM CELLS Translational Medicine article from researchers led by

Fascin1 Supports Mouse ESC Pluripotency

New research led by Bo Li and Xi‐Qiao Feng (Tsinghua University, Beijing, China) recently reported the abundant expression of Fascin1, an actin-bundling protein, in undifferentiated mouse embryonic stem cells (mESCs). Fan et al. demonstrate that Fascin1-overexpressing cells maintain pluripotency but fail to self‐organize into colonies; more specifically, the phosphorylated form of Fascin1 weakens the self‐organization of mESCs.

KDM6A Epigenetically Mediates Reprogramming to Pluripotency

The efficient reprogramming of induced pluripotent stem cells (iPSCs) from somatic cells has relevance to the development of effective stem cell therapies.

Towards a Characterization of Cultured Cardiac Interstitial Cell Adaptability

A study implicates in vitro expansion as a primary determining factor in cardiac interstitial cell adaptability and highlight a role for the host tissue microenvironment

Deciphering the Crucial Roles of Metabolites in the Regulation of Pluripotency

Researchers demonstrate that nicotinamide adenine dinucleotide supports the pluripotent state of human embryonic stem cells through the regulation of metabolism

Improved Pancreatic Differentiation Via Cytoskeletal Targeting

Research suggests that the actin cytoskeleton can significantly impact the differentiation of human pluripotent stem cells into functional pancreatic β cells

Preclinical Safety Studies of hESC-RPE

A recent STEM CELLS Translational Medicine study from the laboratory of

LincRNA Q Modulated the Pluripotency of ESCs

A new STEM CELLS study from Songcheng Zhu and Jiuhong Kang (Tongji University, Shanghai, Chi


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