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ESCs/iPSCs

Heart-specific Laminin Isoform Aids Cardiovascular Progenitor Generation for Cardiac Therapy

Researchers develop a new clinically relevant protocol to differentiate hPSCs into cardiovascular progenitors that can generate cardiomyocytes in vivo

Single Cell RNA-Sequencing Reveals the Inner Complexity of Stem Cell-derived Retinal Organoids

High-throughput Integrated Fluidic Circuits for single-cell RNA sequencing describes embryonic stem cell‐derived retinal organoids during differentiation

Deriving Dopaminergic Neurons from Human Pluripotent Stem Cells: The Current Status and the Way Forward

Systematic evaluation of methods to differentiate dopaminergic neurons from hPSCs identifies measures to improve comparisons and clinical translation

Clustering-mediated Functional Maturation of Pluripotent Stem Cell-derived Pancreatic Cells

Immature hPSC-derived pancreatic β cell clustering in vitro promotes the generation of mature β cells that resemble their endogenous counterparts

Effector of G Protein-coupled Receptors Identified as Novel Pluripotency Factor

New research highlights the influence of a GPCR effector on the maintenance of hESC pluripotency and the successful reprogramming of fibroblasts to hiPSCs 

Gene-editing in Induced Pluripotent Stem Cells Reveals How Risk Locus Influences Cardiovascular Disease

Researchers describe how a risk locus impacts VSMC related genes expression, thereby influencing the risk of coronary artery disease and possibly other CVDs 

Moving Pluripotent Stem Cell-derived Hepatocytes One Step Closer to the Clinic

New research highlights the suitability of hepatocytes differentiated from cGMP human pluripotent stem cells for therapeutic applications in human patients

Induced Pluripotent Stem Cells and CRISPR/Cas9 Combine to Develop in vitro Chondrogenesis Platform

A new study shows how genome editing of induced pluripotent stem cells may pave the way for the development of in vitro chondrogenesis platforms

Mouse Brain Transplantation Permits in vivo Imaging Analysis of Human Neuron Dynamics

Researchers study human iPSC-derived neurons following transplantation into the mouse brain to understand healthy and diseased neuronal dynamics in vivo

First Report of Bipaternal Mice: Dad’s Turn to Cross the Same-sex Reproduction Barrier

A new study explores DNA methylation, imprinting barriers, and uniparental reproduction and reports the first generation of full-term bipaternal mice

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