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ESCs/iPSCs

How Metabolism Impacts the Maturity of iPSC-derived Endothelial Cells

Lowering the intracellular pH can induce the maturation of endothelial cells derived from human induced pluripotent stem cells and hence enhance their regenerative potential

Stem Cell Platform for Evaluation of Nanoplastics

A plethora of plastic types, particle sizes, and a lack of reliable models combine to make the study of environmental plastic pollution on human health a challenging task. 

hiPSC-derived Cortical Neurons

Neuronal replacement by stem cell transplantation represents a potential therapy for neurodegenerative diseases. 

Single‐cell Analysis of RGC Development

Recent advances in single‐cell transcriptomics are paving the way for a comprehensive understanding of disease modeling in terms of cellular complexity and dysregulated genes/signaling pathways.

Replicates in Stem Cell Models

The routine differentiation of human pluripotent stem cells into a multitude of desired cell types has increased the complexity of the requirement for technical or biological replicates in stem cell‐based experimental studies.

Maturation in hiPSC‐derived Cardiac Muscle

Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) have enormous potential in the modeling of human cardiac function and disease; however, these cells are limited by their physiologic immaturity.

Improved Generation of Ventral Midbrain Neurons from Human Induced Pluripotent Stem Cells

An improved protocol for the generation of ventral midbrain neurons from human iPSCs may promote the development of novel cell-therapies for Parkinson’s disease patients

Improving Stem Cell Therapy for Diabetes by Naïve Reversion of iPSCs

The chemical reversion of human iPSCs to a naïve state permits the differentiation of vascular progenitor cells with an improved ability to treat diabetes-related conditions

Resolving the Role of P53 in ESCs

Earlier efforts to identify a role for p53 in controlling the pluripotency of embryonic stem cells (ESCs) have generated contradictory conclusions.

iPSC-derived Endothelial Cells - A Promising new Approach for Hemophilia A Treatment

Endothelial cells differentiated from patient-specific induced pluripotent stem cells can function as clotting factor delivery vehicles for the treatment of hemophilia A

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