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GlcSph in GD-iPSC-derived Neurons Deregulates Lysosomes

Elevated glucosylsphingosine levels activate mTORC1 to interfere with normal lysosomal biogenesis and autophagy in iPSC-derived neurons

Induced DNA Repair Generates Genetically Stable iPSCs

CYCLIND1 mRNA transfection helps to repair DNA during reprogramming to pluripotency, resulting in a genetically stable footprint in human iPSCs

An iPSC-based Cell Cotransplantation Therapy for Critical Limb Ischemia

iPSC‐derived smooth muscle cells enhance the therapeutic efficacy of iPSC‐derived endothelial cells after cotransplantation in a murine hindlimb ischemia model

Transcription Factor Combo Drives Oocyte Production from Mouse ESCs

A combination of eight transcription factors that orchestrate oocyte growth can also prompt the conversion of mouse embryonic stem cells into oocyte-like cells

Small-molecule Compound Promotes Function of Cells Carrying Mitochondrial Mutations

A small-molecule compound that activates mitochondrial respiration can rescue defects to neuronal differentiation in iPSCs carrying mutant mitochondrial DNA

Neurotrophin‐3 Protects Cardiovascular Progenitor Cells from I/R-Injury

Neurotrophin‐3 secreted from human ESC-derived cardiovascular progenitor cells may protect from  ischemia/reperfusion injury

Exploring the Immunogenicity of Human iPSC-derived Cells

While transplanted human iPSC-derived skeletal muscle cells become infiltrated by immune cells after transplantation, this does not negatively impact engraftment

iPSC-derived Heart-on-a-Chip System Takes Another Step Forward

A study reports a microfluidic “heart-on-a-chip” system and its validation via an analysis of responses to electrical stimulation and drug administration

GPC4 Regulates Neuronal Differentiation of iPSCs

GPC4 downregulation prompts efficient differentiation of iPSCs into dopaminergic neurons

Deciphering LIF-mediated ESC Pluripotency

JAK2 mediates the epigenetic control of pluripotency in mouse embryonic stem cells


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