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ESCs/iPSCs

Cp40 Reverses Pathology in AMD-RPE

The modulation of the complement system may represent a useful therapeutic approach for AMD cases associated with complement dysregulation.

Adjuvant Therapy for Cardiac Cell Transplantation

sEHIs results in a significant increase in the retention of transplanted cells and an improvement in cardiac function 

Accelerated Neural Differentiation of hPSCs

A new study removes a historical bottleneck that has hindered improvement to the control and speed of generating neural cells from hPSCs.

Perspective on Cardiac Application Of hPSCs

The ability to generate multiple cardiac cell types from human pluripotent stem cells will provide researchers with the means to evaluate their application in the repair of damaged myocardium.

Preclinical Safety Study Provides Support for hESC-RPE as a Vison Loss Treatment

Wide-raging analyses support the safety of human embryonic stem cell‐derived retinal pigment epithelium generated by an optimized in vitro differentiation methodology

Non-invasive Tracking of iPSC-Cardiomyocytes

A proof‐of‐principle study reports on the sensitive in vivo tracking of iPSC‐CMs in a clinically relevant model of myocardial infarction

Gene Editing to Install a Safety Switch in iPSC

Researchers now describe the improved design and in vitro and in vivo testing of a novel inducible “suicide switch” safety system for iPSC‐derived cell‐based therapies

DNMT3B Controls Metabolic Flux of hESCs

A new study reveals a link between DNA methyltransferase 3B and metabolic flux in human embryonic stem cells

GABAergic Interneuron Generation from PSCs

A new article considers the progress and discusses the remaining challenges regarding the use of stem cell-derived cortical interneurons in the study and treatment of forebrain disease

E-cad Promotes the Primed Pluripotent State

Transition from the naïve to the primed state of pluripotency associates with the epithelial to mesenchymal transition (EMT) and a metabolic switch 

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