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Differentiation Variability to Retinal Organoids

Using two different differentiation approaches involving either BMP4 or IGF1 signaling pathways, researchers led by Lyle Armstrong (Newcastle University, UK) recently derived retinal organoids from three human induced pluripotent stem cell (iPSC) lines. Chichagova et al.

Pluripotent Stem Cells and Genetic Heart Diseases

A new review article from the laboratory of Richard P. Davis (Leiden University Medical Center.

Control of ESC-to-NPC Transition by TGFβ/BMP Signaling

Extrinsic cell signaling is transmitted through intracellular proteins that converge on gene transcription to steer cell fate and differentiation. The study of the roles of such top‐down pathways during development has historically employed single‐component perturbations with read‐out time points covering multiple developmental stages.

Enhancing Cone and Rod Generation from hPSCs

The generation of retinal organoids from human pluripotent stem cells (hPSCs) provides an in vitro approach to disease modeling and replacement therapies; however, the efficiency of described protocols for the generation of retinal organoids remains variable, resulting in the emergence of all retinal cell types, including photoreceptors, but in different ratios and at different maturation stag

Simple Two Small-Molecule Compound Approach to the Chondrogenic Differentiation of iPSCs

Treatment of human iPSCs with two small-molecule compounds robustly induces the formation of chondrocytes that form hyaline cartilaginous tissues in vivo

Pacemaker Cell Specification of Cardiac Mesoderm

Despite recent advances in cardiac chamber‐specific differentiation of pluripotent stem cells, the molecular drivers that dictate cardiac pacemaker cell differentiation remain incompletely understood.

A Step Towards the Epigenetic Understanding of Early Human Development

A new study highlights the importance of SMYD2-mediated epigenetic modifications to the early lineage commitment of human embryonic stem cells

The Dynamic Role of Connexins in Pluripotency

Although pluripotent stem cells express connexins, the role of connexin‐mediated gap junctional intercellular communication remains controversial. However, a new study from Jessica L.

Human Motor Neuron and Astrocytes in MEA

Researchers from the laboratory of Nicholas J.

Organoids and Retinal Diseases: A Review

Three-dimensional retinal organoids display enormous potential for the investigation of the pathogenesis of monogenic hereditary eye diseases related to the malfunction or degeneration of photoreceptors or retinal ganglion cells (RGCs) by providing an amenable in vitro tool with multiple applications.


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