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Optimized Platform Boosts Studies of Rare Neurodevelopmental Disorders

A new study describes a quick and efficient means to generate, gene-edit, and differentiate induced pluripotent stem cells in order to study rare neurodevelopmental disorders

Totipotency – Just an miRNA Away?

A new study shows that the loss of a single microRNA is sufficient to endow mouse pluripotent stem cells with totipotent characteristics

Search and Destroy: Eliminating Pluripotent Cells from Differentiating Cultures

A new study describes a new synthetic hybrid molecule that can selectively target and eliminate pluripotent cells and reduce the tumorigenic threat of cell transplantation strategies

TGFβ Inhibition – The Key to Endothelial Cell-based Therapeutics?

New research discovers a means to boost the growth and function of endothelial cells derived from human pluripotent stem cells

Pluripotency takes a Pause for Thought!

Researchers discover that modulation of a nutrient-sensing pathway can induce a “paused” state of pluripotency

Senescence - An Unexpected Helper for in vivo Reprogramming

New research into in vivo reprogramming highlights cellular senescence as an important regulator

iPSCs and Gene Correction Technology Team up to Tackle Beta Thalassemia

A new study demonstrates that the combination of iPSCs and gene correction technology may provide a patient-specific means to treat inherited blood disorders

Mapping Strategy Reveals Unexpected Landmarks in the Pluripotent Chromatin Landscape

A new mapping technique permits researchers to uncover unexpected findings regarding nucleosome occupancy in embryonic stem cells

Breaking down Epigenetic Barriers to iPSC Reprogramming

Researchers identify an epigenetic barrier to the production of induced pluripotent stem cells

Fluctuating Ahr Levels Control the Choice between Pluripotency and Differentiation

A new study highlights the important role of aryl hydrocarbon receptor in the regulation of the pluripotent state of mouse embryonic stem cells

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