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Link between the Proteasome and Pluripotency Further Strengthened

Researchers find Nrf2, a stress response gene, to be a pluripotency gene which mediates its effects through regulation of the proteasome

Human iPSC-Derived Neural Cells Form Extensive Neural Networks in Rodents

A new study finds that neural cells derived from human induced pluripotent stem cells can form an extensive axonal network in a rodent model

iPSC Model Links Neuropsychiatric-associated Genetic Defects to Synaptic Deficits

Scientists link a common mutation in patients with neuropsychiatric disorders to deregulated neuronal synapses through generating patient-specific induced pluripotent stem cells and following their differentiation

Neural Stem Cells from iPSCs – Not so Safe After All?

Researchers find that neural stem cells, but not terminally differentiated neural cell types, differentiated from iPSCs can revert to a pluripotent like state and potentially problematic for use in transplants.

Transgene Free iPSCs Yield Cells with Greater Functionality

Residual transgenes present after piggyBac-mediated human iPSC production affect the functionality of keratinocytes derived from such iPSCs compared to iPSCs completely free of transgene sequences

Towards the Clinical Implementation of ESC-derived Cardiac Cells

Using a non-human primate model, researchers demonstrate that sufficient numbers of human ESC-derived cardiomyocytes can be produced, stored, and transplanted, leading to good levels of engraftment and electrical coupling

Epigenetic Link to Cell Cycle Regulation in human ESCs

Histone demethylation through JMJD5 is found to be vital for the cell cycle and maintenance of pluripotency in embryonic stem cells

Reprogramming: The Prize for the Best Pluripotent Stem Cell Goes To………

Comparisons of genetically matched human pluripotent stem cells reveals that somatic cell nuclear transfer is the ideal means of generating cells for replacement therapy

iPSC-Derived Modified Endothelial Progenitor Cells Repress Tumorigenesis

Endothelial progenitor cells derived from induced pluripotent stem cells which target tumors can be modified to carry an anti-tumorigenic “payload” and promoter tumor growth inhibitionsy

Stable Fluorescent Labelling of human iPSCs aid Cell Tracking after Differentiation and Transplantation: Strategies and Pitfalls!

A new study outlines the design and generation of a fluorescent induced pluripotent stem cell line for tracking cells post-differentiation after transplantation, describing problems and solutions along the way.


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