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ESCs/iPSCs

Microfluidic Platform Models Early Human Development with Human Pluripotent Stem Cells

Culture of pluripotent stem cells within a microfluidic platform allows the exploration of the developmental processes taking place in the early human embryo

Reviewing the Role of EVs in Stem Cell Biology

The ability of cells to communicate with their surroundings by producing different classes of extracellular vesicles (EVs) plays an important role in physiological and pathological processes. Now, researchers led by Richard A.

MicroRNA‐124a Inhibits mESC Endoderm Differentiation

Researchers from the lab of Takahiro Ichiya (Tokyo Medical University, Tokyo, Japan) recently revealed an additional role for miR‐124a in the early development of mouse embryonic stem cells mESCs in a STEM CELLS

How iPSC Therapy Reduces Endothelial Leakage in an Acute Lung Injury Model

Induced pluripotent stem cell therapy reduces endothelial cell leakage after acute lung injury through a pathway involving TIMP‐1 and the FAK/Snail pathway

Pluripotent Stem Cell-derived Neuruloids - A New Approach to Developmental Analysis and Disease Modeling

Generation of PSC-derived neuruloids hopes to provide insight into human development and a range of poorly understood human genetic diseases and pediatric cancers

TIMP Proteins Inhibit PSC-derived Teratoma Formation

The ablation of proliferative pluripotent stem cells (PSCs) before or after the transplantation of PSC-derivatives would significantly reduce associated risks, including teratoma formation.

Linc1557 Initiates Mouse ESC Differentiation

In a recent STEM CELLS article, researchers from the laboratories of Guiying Wang and Jiuhon

hPSC‐derived Organoids in Tissue injury and Repair Modeling

As new applications for drug‐screening and tissue replacement therapies emerge, we must examine the mechanisms of tissue injury and fibrosis in human pluripotent stem cell (hPSC)‐derived mini-organs and evaluate if organoid tissues recapitulate the mechanisms of tissue damage and regeneration observed in vivo. A new review article from Maria F. S.

Influence of Thyroid Hormone on Human Embryos

Thyroid hormones are regarded as the significant controllers of metabolic rate and oxygen consumption in mammals; however, we know little about their effects in the earliest stages of human development.

Identifying Stem Cell-derived Cardiomyocytes

Current differentiation methods for generating human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) yield heterogeneous populations - a fact that represents a critical barrier for downstream applications that require well‐defined populations. Furthermore, we lack markers that identify undesired populations such as teratoma‐forming or arrhythmia‐inducing cells.

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