ESCs/iPSCs

Residual transgenes present after piggyBac-mediated human iPSC production affect the functionality of keratinocytes derived from such iPSCs compared to iPSCs completely free of transgene sequences

Using a non-human primate model, researchers demonstrate that sufficient numbers of human ESC-derived cardiomyocytes can be produced, stored, and transplanted, leading to good levels of engraftment and electrical coupling

Histone demethylation through JMJD5 is found to be vital for the cell cycle and maintenance of pluripotency in embryonic stem cells

Comparisons of genetically matched human pluripotent stem cells reveals that somatic cell nuclear transfer is the ideal means of generating cells for replacement therapy

Endothelial progenitor cells derived from induced pluripotent stem cells which target tumors can be modified to carry an anti-tumorigenic “payload” and promoter tumor growth inhibitionsy

A new study outlines the design and generation of a fluorescent induced pluripotent stem cell line for tracking cells post-differentiation after transplantation, describing problems and solutions along the way.

Researchers detail their assessment of the autologous transplantation of Rhesus macaque induced pluripotent stem cells and their derivatives as a relevant means to model their clinical application.

Light-sensitive photoreceptors have been created in the lab for the first time from stem cells.

An improved differentiation strategy allows the production of iPSC-derived lung cells with improved regenerative and reparative potential.

Authors show that astrocyte progenitors engraft into the spinal column and differentiate into astrocytes, survival long term and may have great utility in therapy and disease modelling