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Making cardiomyocytes from Pluripotent Cells: Pure and Simple!

A large scale differentiation system combined with metabolomic purification yields pure and functional cardiomyocytes from human pluripotent stem cells

Creation of Human Intestine from Human Pluripotent Stem Cells

An in vivo maturation step mediates the generation of organoids resembling mature intestinal tissue from human pluripotent stem cells

Enhancing ESC-derived Therapies for Age Related Disorders

Improved production of retinal cells from embryonic stem cells brings this therapy closer to the clinic.

Higher Developmental State Reached in Human Pluripotent Cells

Human pluripotent stem cells brought to their highest developmental state, carrying with them the promise of the study of early human development and advances in regenerative medicine

iPSC Production – Select Your Factors Wisely

More is not always better in reprogramming, as researchers show that a set of factors which reprogram cells with low efficiency are developmentally superior to other more “efficient” reprogramming cocktails.

Stem Cells Get Motoring!

Motor neuron diseases encompass a range of neurological disorders that affect the muscles and movement of the body. These disorders are caused by the progressive degeneration of motor neurons, often leading to paralysis and ultimately death in patients. Can a stem cell-based strategy provide replacement cells?

Link between the Proteasome and Pluripotency Further Strengthened

Researchers find Nrf2, a stress response gene, to be a pluripotency gene which mediates its effects through regulation of the proteasome

Human iPSC-Derived Neural Cells Form Extensive Neural Networks in Rodents

A new study finds that neural cells derived from human induced pluripotent stem cells can form an extensive axonal network in a rodent model

iPSC Model Links Neuropsychiatric-associated Genetic Defects to Synaptic Deficits

Scientists link a common mutation in patients with neuropsychiatric disorders to deregulated neuronal synapses through generating patient-specific induced pluripotent stem cells and following their differentiation

Neural Stem Cells from iPSCs – Not so Safe After All?

Researchers find that neural stem cells, but not terminally differentiated neural cell types, differentiated from iPSCs can revert to a pluripotent like state and potentially problematic for use in transplants.


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