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How Integrins Maintain the Pluripotent State

A new study describes the importance of the integrin transmembrane receptors and how the help to maintain the pluripotent state

ESCs Need a Pause for Lineage-Specific Differentiation

New cell cycle studies of the human embryonic stem cells suggests that a G2 pause is required for lineage-specific differentiation

Creating Safer Stem Cell Therapies with Naked Mole Rat iPSCs!

The creation of naked mole rate iPSCs may provide us clues on how to create safer human stem cell therapies

A Quick and Easy Strategy for Cerebral Organoid Production

Researchers describe a new quick and easy method to produce “mini” brains, or cerebral organoids, which may aid the construction of new therapeutic treatment strategies

Big Consequences of a Little Carry-over in Mitochondrial Replacement Therapy

A new study suggests that while mitochondrial replacement therapy may be successful in the treatment of mitochondrial disease, small amounts of mitochondrial carry-over can allow disease reappearance

iPSC-Derived Retinal Ganglion Cells: A New Tool in the Battle Against Optic Neuropathies

A new study describing the differentiation of retinal ganglion cells from human pluripotent stem cells may provide a new tool to study optic neuropathies

iPSC-Reprogramming Keeps it Nice and Splice-y!

New research highlights the importance of alternative splicing at various stages of iPSC reprogramming

Correlation of Age and Mitochondrial Mutations in iPSCs

Research suggests that iPSCs generated from older patient samples are more likely to carry higher levels of mitochondrial DNA damage which could affect their therapeutic application

Microchamber, Mega mESC Pluripotency!

Researchers successfully apply a microchamber culture strategy for mESCs which potentiates endogenous signaling to promote pluripotency

Tackling Loss of Hearing with Mutation Correction of Patient Specific Stem Cells

Using patient specific induced pluripotent stem cells, a new study shows that cell-based treatments for deafness may be a future possibility


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