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ESCs/iPSCs

New Advance Hastens the Production of Neural Cells from Human Pluripotent Stem Cells

A new study reports the efficient and rapid differentiation of human PSCs into a neural precursor population with early intermediate ectodermal characteristics

Drug Screening for Nakajo-Nishimura Syndrome

HDAC inhibitor identified as a Nakajo‐Nishimura syndrome treatment by screening using PSC‐derived monocytic cell lines

CAG Promoter Activity and Reprogramming

A novel and simple methodology an identify and enrich somatic cells correctly undergoing reprogramming into induced pluripotent stem cells

Exploring Human Stem Cell Therapies for Cerebral Cortex Disorders in Human Organotypic Culture

Functional engraftment of human iPSC-derived neurons into a human adult host neural network may boost the clinical translation of novel cerebral cortex treatments

Eradicating PSCs with DHODH Inhibitors

An inhibitor of dihydroorotate dehydrogenase specifically induces elevated levels of cytotoxicity in mouse PSCs

Towards the Three-dimensional Bioprinting of a Human Heart

Researchers use induced pluripotent stem cells grown and differentiated within an extracellular matrix bioink to develop a chambered muscle pump

MicroRNA-mediated ESC Cardiac Mesoderm Differentiation

A new report explores how the microRNA184/Wnt3 signaling pathway modulates the cardiac mesoderm differentiation of ESCs

Chemotherapeutic Selection of iPSCs for PD

Non-genetic methodologies to reduce undesirable proliferation represent a valuable tool when generating dopamine neurons from induced pluripotent stem cells

Contractile Protein Isoform Switch Prompts iPSC-derived Cardiomyocytes to Mature

Sarcomeric maturation and the induction of adult-like function following TnI expression may foster the therapeutic application of in hiPSC‐derived cardiomyocytes

hiPSC Organoids Model Lung Disorder

New lung organoid model allows the identification of primary cell‐intrinsic and secondary causes of congenital diaphragmatic hernia lung hypoplasia

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