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Microfluidics and Autologous Cell Replacement

A review article discusses the application of state-of-the-art microfluidic devices to stem cell transfection and post-differentiation cell enrichment

iPSC-model of SARS-CoV-2 Upper Airway Infection

Researchers describe the development of an induced pluripotent stem cell-derived model of SARS-CoV-2 infection/replication in the upper airways

Zbtb46 Induces ESC-derived Hematopoietic Progenitors

Researchers probe the function of Zbtb46 in embryonic stem cell-derived blood cell progenitors using chemically inducible transgenic cell lines

JAK2-mediated Epigenetic Alterations Support the Pluripotency of Mouse ESCs

JAK2 plays a novel epigenetic regulatory role that supports the maintenance of the pluripotent state of mouse embryonic stem cells

Yap Isoforms Control ESC Self‐renewal and Differentiation

A new study describes the multifaceted and cell state‐dependent role of Yap isoforms in embryonic stem cell fate decision

Nodal Signaling in hPSCs

A new review discusses recent studies that have clarified the role of Nodal signaling in the maintenance and differentiation of human pluripotent stem cells

GPC4 Downregulation in iPSCs Promotes Differentiation into Dopaminergic Neurons that Rescue Parkinson's Disease Symptom

Researchers describe an alternative approach to the differentiation of human iPSCs into ventral midbrain dopaminergic neurons that can be used to treat Parkinson's disease

Fluid Shear Stress Promotes ESC Pluripotency

Fluid shear stress supports mouse embryonic stem cell pluripotency and obviates the need to add leukemia inhibitory factor to bioreactor culture

NT‐3 Treatment as a Novel Cell-free Therapeutic Approach for Myocardial Infarction-associated Injury

New research supports the use of Neurotrophin‐3 treatment as a novel cell-free therapeutic approach for myocardial infarction-associated injury

Identifying the Gene Regulatory Networks Controlling Efficient Human iPSC Chondrogenesis

Inhibiting the expression of specific WNTs and MITF during the chondrogenic differentiation of human iPSCs significantly increases chondrocyte homogeneity


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