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Slow and Sure Wins the iPSC Race?

New research suggests that increasing the proliferative rate of fibroblasts before reprogramming actually reduces the efficiency of iPSC formation.

Humanized Mice Aid the Study of Immune Response to hiPSC-derived Cells

Using a mouse model with a human immune system, researchers find that not all induced pluripotent stem cell derivatives are equal, immunologically speaking.

Reduction in Immunogenicity May Boost ESC-based Therapies

Disruption of the antigen-presenting system in hESCs generates cells with reduced immunogenicity, in what could be the first step towards creating immuneprivileged, and universally accepted cells/tissues.

Understanding Autism with Patient-Specific Stem Cell Derived Brain Organoids

Exciting new study combining iPSCs and 3D organoid cultures discovers that stem cell amplification due to the overexpression of FOXG1 may lie at the root of autism spectrum disorder.

Naïve Pluripotency - New Direction, Same Destination

A new and easy method of inducing the naïve pluripotent state in human embryonic stem cells is described in a new study

Inducible Gene Knockouts in Human Stem Cells: CRISPR Hits the Headlines Again

Generating inducible gene knockout in human pluripotent stem cells may open up a new level of understanding the roles of genes and groups of genes in pluripotency and differentiation.

Microvesicles from Pluripotent Stem Cells Enhance Cardiac Regenerative Potential

Researchers demonstrate the pro-regenerative effects of exosomes derived from induced pluripotent stem cells and highlight a possible role for exosomes in tissue repair.

Patient-specific Neural Progenitor Therapy Preserves Visual Function

Neural progenitors derived from induced pluripotent stem cells are shown to reverse retinal degeneration and may represent an effective therapy to prevent the loss of vision

Can Engineered Bacteria Bring Gene-edited Human Stem Cells to the Clinic?

Researchers describe how a bacterial infection-based protein delivery strategy can mediate effective and safe gene editing in human pluripotent stem cells.

New Pluripotent Stem Cell Type with Enhanced Therapeutic Value Described

Researchers describe "region-selective" pluripotent stem cells from mouse and humans, and highlight their therapeutic potential.


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