ESCs/iPSCs

Endothelial progenitor cells derived from induced pluripotent stem cells which target tumors can be modified to carry an anti-tumorigenic “payload” and promoter tumor growth inhibitionsy

A new study outlines the design and generation of a fluorescent induced pluripotent stem cell line for tracking cells post-differentiation after transplantation, describing problems and solutions along the way.

Researchers detail their assessment of the autologous transplantation of Rhesus macaque induced pluripotent stem cells and their derivatives as a relevant means to model their clinical application.

Light-sensitive photoreceptors have been created in the lab for the first time from stem cells.

An improved differentiation strategy allows the production of iPSC-derived lung cells with improved regenerative and reparative potential.

Authors show that astrocyte progenitors engraft into the spinal column and differentiate into astrocytes, survival long term and may have great utility in therapy and disease modelling

Adenovirally generated induced pluripotent stem cells mediate a preservation of motor function or behavioral recovery after transplantation in a mouse model of Huntington’s Disease

While antiviral therapy for AIDS has been successful, new strategies are required to remove the virus from remaining cellular reservoirs. The laboratory of Dan S. Kaufman have now created an engineered pluripotent stem cell derived immune cell to target the suppression of HIV replication. The groups in vitro analyses finds that their engineered cells are more effective than non-engineered, and in vivo analyses shows some promise for the future. Overall, engineering strategies such as this may be the future of patient-specific anti-viral therapeutics.

• Will long term treatment with NK cells abolish HIV infection?
• What other strategies can we adapt to target HIV?
• Is this strategy a viable option for many HIV sufferers?