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Bivalent Metabolism Maintains hESC Pluripotency

Nicotinamide adenine dinucleotide (NAD+) induces an intermediate state of naivety in human embryonic stem cells (hESCs) characterized by a shift from glycolytic to oxidative metabolism, increased self‐renewal, and epigenetic alterations. Conversely, inhibition of the malate aspartate shuttle (MAS), which recycles NAD+, causes a dramatic loss of oxidative metabolism and pluripotency marker expression.

Oct4 Plays Detrimental Role in Mouse Induced Pluripotent Stem Cell Generation

The generation of induced pluripotent stem cell employing the lentiviral transduction of Sox2, Klf4, and Myc only generates cells with improved developmental potential

Enhanced Disease Modeling and Treatment Opportunities with Human ESC-Derived Expandable Hepatic Organoids

A new organoid generation protocol may provide the means to generate powerful in vitro models to study therapeutic approaches to a range of liver diseases and disorders

Inflammatory Factors from Aged Fibroblasts Affect Reprogramming and Wound Healing

Alteration of fibroblast composition and increased inflammatory cytokine secretion during aging drives reprogramming variability in vitro and wound healing rate in vivo

Linking Connexin Expression to the Pluripotent State of Stem Cells

A detailed evaluation of the expression levels of connexin genes in pluripotent stem cells reveals that connexin levels depend on the stem cell state

Sphingosine Levels Key for Maintaining Stem Cell Fate

The function of the sphingosine‐1‐phosphate (S1P) signaling pathway in embryonic stem cells (ESCs) remains unclear; therefore, researchers led by Todd Evans

Using AMD Patient iPSCs to Model Disease

Age‐related macular degeneration (AMD), a multifactorial disease of primates, has confounded efforts that aim to model the disease in laboratory animals or during in vitro culture. However, researchers led by Mark A.

Determining a Fundamental Role for APC in hESC Self-renewal

Research highlights the requirement for constant β‐catenin degradation via adenomatous polyposis coli activity to support human embryonic stem cell self-renewal


Microfluidic Platform Models Early Human Development with Human Pluripotent Stem Cells

Culture of pluripotent stem cells within a microfluidic platform allows the exploration of the developmental processes taking place in the early human embryo

Reviewing the Role of EVs in Stem Cell Biology

The ability of cells to communicate with their surroundings by producing different classes of extracellular vesicles (EVs) plays an important role in physiological and pathological processes. Now, researchers led by Richard A.


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