ESCs/iPSCs

Short term T-cell mediated immune response blockade promotes the functionality of hESC-derivative grafts in immune-competent mice.

Cheap and simple growth substrates are discovered to aid differentiation of stem cells as compared to more complex and expensive alternatives
ESC/iPSCs

A quick and easy differentiation protocol for neural stem cells and their derivatives from human induced pluripotent stem cells

A large scale differentiation system combined with metabolomic purification yields pure and functional cardiomyocytes from human pluripotent stem cells

An in vivo maturation step mediates the generation of organoids resembling mature intestinal tissue from human pluripotent stem cells

Improved production of retinal cells from embryonic stem cells brings this therapy closer to the clinic.

Human pluripotent stem cells brought to their highest developmental state, carrying with them the promise of the study of early human development and advances in regenerative medicine

More is not always better in reprogramming, as researchers show that a set of factors which reprogram cells with low efficiency are developmentally superior to other more “efficient” reprogramming cocktails.

Motor neuron diseases encompass a range of neurological disorders that affect the muscles and movement of the body. These disorders are caused by the progressive degeneration of motor neurons, often leading to paralysis and ultimately death in patients. Can a stem cell-based strategy provide replacement cells?

Researchers find Nrf2, a stress response gene, to be a pluripotency gene which mediates its effects through regulation of the proteasome