ESCs/iPSCs

A new study highlights the importance of SMYD2-mediated epigenetic modifications to the early lineage commitment of human embryonic stem cells

Although pluripotent stem cells express connexins, the role of connexin‐mediated gap junctional intercellular communication remains controversial. However, a new study from Jessica L.

Researchers from the laboratory of Nicholas J.

Three-dimensional retinal organoids display enormous potential for the investigation of the pathogenesis of monogenic hereditary eye diseases related to the malfunction or degeneration of photoreceptors or retinal ganglion cells (RGCs) by providing an amenable in vitro tool with multiple applications.

The directed differentiation of induced pluripotent stem cells (iPSCs) provides a scalable means to generate therapeutically relevant numbers of dendritic cells (DCs); however, as with many iPSC-derived cell types, iPSC-DCs do not reach full functional maturity and display limited immunogenicity. Researchers from the lab of Paul J.

Induced pluripotent stem cells (iPSCs) significantly diminish the severity of endotoxin‐induced acute lung injury (ALI); however, the interactions that occur between iPSCs and the vascular endothelium remain unclear.

A new study combines skeletal myocyte differentiation of mutation-carrying hiPSCs with drug screen to detect small molecules that boost dysferlin levels

While genetically encoded fluorescent voltage indicators can report on action potentials in human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs), the transfection process presents several drawbacks. To solve this problem, researchers from the laboratory of Deborah K.

To study the role of Adenomatous polyposis coli (APC), a negative regulator of Wnt/β‐catenin signaling, in human embryonic stem cells (ESCs), researchers from the lab of Dalit Ben‐Yosef

FUCCI technology tracks cell division in primed hPSCs to highlight the importance of distinct signaling pathways in regulation of developmental potential