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ESCs/iPSCs

A Step Towards the Epigenetic Understanding of Early Human Development

A new study highlights the importance of SMYD2-mediated epigenetic modifications to the early lineage commitment of human embryonic stem cells

The Dynamic Role of Connexins in Pluripotency

Although pluripotent stem cells express connexins, the role of connexin‐mediated gap junctional intercellular communication remains controversial. However, a new study from Jessica L.

Human Motor Neuron and Astrocytes in MEA

Researchers from the laboratory of Nicholas J.

Organoids and Retinal Diseases: A Review

Three-dimensional retinal organoids display enormous potential for the investigation of the pathogenesis of monogenic hereditary eye diseases related to the malfunction or degeneration of photoreceptors or retinal ganglion cells (RGCs) by providing an amenable in vitro tool with multiple applications.

Creating Immunostimulatory Dendritic Cells From iPSCs

The directed differentiation of induced pluripotent stem cells (iPSCs) provides a scalable means to generate therapeutically relevant numbers of dendritic cells (DCs); however, as with many iPSC-derived cell types, iPSC-DCs do not reach full functional maturity and display limited immunogenicity. Researchers from the lab of Paul J.

iPSCs Reduce Pulmonary Endothelial Leakage

Induced pluripotent stem cells (iPSCs) significantly diminish the severity of endotoxin‐induced acute lung injury (ALI); however, the interactions that occur between iPSCs and the vascular endothelium remain unclear.

iPSC-based Small Molecule Screening Reveals Possible Dysferlinopathy Treatment Approach

A new study combines skeletal myocyte differentiation of mutation-carrying hiPSCs with drug screen to detect small molecules that boost dysferlin levels

Engineered hiPSC-CMs for Action Potential Assessments

While genetically encoded fluorescent voltage indicators can report on action potentials in human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs), the transfection process presents several drawbacks. To solve this problem, researchers from the laboratory of Deborah K.

Functional APC Required for ESC Self-renewal

To study the role of Adenomatous polyposis coli (APC), a negative regulator of Wnt/β‐catenin signaling, in human embryonic stem cells (ESCs), researchers from the lab of Dalit Ben‐Yosef

Tracking Pluripotent Stem Cells Through the Cell Cycle

FUCCI technology tracks cell division in primed hPSCs to highlight the importance of distinct signaling pathways in regulation of developmental potential

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