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ESCs/iPSCs

Linc1557 Initiates Mouse ESC Differentiation

In a recent STEM CELLS article, researchers from the laboratories of Guiying Wang and Jiuhon

hPSC‐derived Organoids in Tissue injury and Repair Modeling

As new applications for drug‐screening and tissue replacement therapies emerge, we must examine the mechanisms of tissue injury and fibrosis in human pluripotent stem cell (hPSC)‐derived mini-organs and evaluate if organoid tissues recapitulate the mechanisms of tissue damage and regeneration observed in vivo. A new review article from Maria F. S.

Influence of Thyroid Hormone on Human Embryos

Thyroid hormones are regarded as the significant controllers of metabolic rate and oxygen consumption in mammals; however, we know little about their effects in the earliest stages of human development.

Identifying Stem Cell-derived Cardiomyocytes

Current differentiation methods for generating human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) yield heterogeneous populations - a fact that represents a critical barrier for downstream applications that require well‐defined populations. Furthermore, we lack markers that identify undesired populations such as teratoma‐forming or arrhythmia‐inducing cells.

Differentiation Variability to Retinal Organoids

Using two different differentiation approaches involving either BMP4 or IGF1 signaling pathways, researchers led by Lyle Armstrong (Newcastle University, UK) recently derived retinal organoids from three human induced pluripotent stem cell (iPSC) lines. Chichagova et al.

Pluripotent Stem Cells and Genetic Heart Diseases

A new review article from the laboratory of Richard P. Davis (Leiden University Medical Center.

Control of ESC-to-NPC Transition by TGFβ/BMP Signaling

Extrinsic cell signaling is transmitted through intracellular proteins that converge on gene transcription to steer cell fate and differentiation. The study of the roles of such top‐down pathways during development has historically employed single‐component perturbations with read‐out time points covering multiple developmental stages.

Enhancing Cone and Rod Generation from hPSCs

The generation of retinal organoids from human pluripotent stem cells (hPSCs) provides an in vitro approach to disease modeling and replacement therapies; however, the efficiency of described protocols for the generation of retinal organoids remains variable, resulting in the emergence of all retinal cell types, including photoreceptors, but in different ratios and at different maturation stag

Simple Two Small-Molecule Compound Approach to the Chondrogenic Differentiation of iPSCs

Treatment of human iPSCs with two small-molecule compounds robustly induces the formation of chondrocytes that form hyaline cartilaginous tissues in vivo

Pacemaker Cell Specification of Cardiac Mesoderm

Despite recent advances in cardiac chamber‐specific differentiation of pluripotent stem cells, the molecular drivers that dictate cardiac pacemaker cell differentiation remain incompletely understood.

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