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Improved Generation of Ventral Midbrain Neurons from Human Induced Pluripotent Stem Cells

An improved protocol for the generation of ventral midbrain neurons from human iPSCs may promote the development of novel cell-therapies for Parkinson’s disease patients

Improving Stem Cell Therapy for Diabetes by Naïve Reversion of iPSCs

The chemical reversion of human iPSCs to a naïve state permits the differentiation of vascular progenitor cells with an improved ability to treat diabetes-related conditions

Resolving the Role of P53 in ESCs

Earlier efforts to identify a role for p53 in controlling the pluripotency of embryonic stem cells (ESCs) have generated contradictory conclusions.

iPSC-derived Endothelial Cells - A Promising new Approach for Hemophilia A Treatment

Endothelial cells differentiated from patient-specific induced pluripotent stem cells can function as clotting factor delivery vehicles for the treatment of hemophilia A

Towards the Development of Xenogeneic Organs with Donor-derived Endothelium

Researchers explore embryo complementation with human induced pluripotent stem cells to rescue ETV2-mutant embryos and generate donor-cell derived hematoendothelium

FGF1‐RUNX2 Signaling in Neural Crest Osteoprogenitors

Given that the human skeleton arises from different embryonic origins, modeling early bone development with human pluripotent stem cells may benefit from a method of lineage‐specific derivation.

hiPSC Serial Expansion in Vertical-wheel Bioreactors

A recent STEM CELLS Translational Medicine article from researchers led by <

Fascin1 Supports Mouse ESC Pluripotency

New research led by Bo Li and Xi‐Qiao Feng (Tsinghua University, Beijing, China) recently reported the abundant expression of Fascin1, an actin-bundling protein, in undifferentiated mouse embryonic stem cells (mESCs). Fan et al. demonstrate that Fascin1-overexpressing cells maintain pluripotency but fail to self‐organize into colonies; more specifically, the phosphorylated form of Fascin1 weakens the self‐organization of mESCs.

KDM6A Epigenetically Mediates Reprogramming to Pluripotency

The efficient reprogramming of induced pluripotent stem cells (iPSCs) from somatic cells has relevance to the development of effective stem cell therapies.

Towards a Characterization of Cultured Cardiac Interstitial Cell Adaptability

A study implicates in vitro expansion as a primary determining factor in cardiac interstitial cell adaptability and highlight a role for the host tissue microenvironment


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