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Linking Connexin Expression to the Pluripotent State of Stem Cells

A detailed evaluation of the expression levels of connexin genes in pluripotent stem cells reveals that connexin levels depend on the stem cell state

Sphingosine Levels Key for Maintaining Stem Cell Fate

The function of the sphingosine‐1‐phosphate (S1P) signaling pathway in embryonic stem cells (ESCs) remains unclear; therefore, researchers led by Todd Evans

Using AMD Patient iPSCs to Model Disease

Age‐related macular degeneration (AMD), a multifactorial disease of primates, has confounded efforts that aim to model the disease in laboratory animals or during in vitro culture. However, researchers led by Mark A.

Determining a Fundamental Role for APC in hESC Self-renewal

Research highlights the requirement for constant β‐catenin degradation via adenomatous polyposis coli activity to support human embryonic stem cell self-renewal


Microfluidic Platform Models Early Human Development with Human Pluripotent Stem Cells

Culture of pluripotent stem cells within a microfluidic platform allows the exploration of the developmental processes taking place in the early human embryo

Reviewing the Role of EVs in Stem Cell Biology

The ability of cells to communicate with their surroundings by producing different classes of extracellular vesicles (EVs) plays an important role in physiological and pathological processes. Now, researchers led by Richard A.

MicroRNA‐124a Inhibits mESC Endoderm Differentiation

Researchers from the lab of Takahiro Ichiya (Tokyo Medical University, Tokyo, Japan) recently revealed an additional role for miR‐124a in the early development of mouse embryonic stem cells mESCs in a STEM CELLS

How iPSC Therapy Reduces Endothelial Leakage in an Acute Lung Injury Model

Induced pluripotent stem cell therapy reduces endothelial cell leakage after acute lung injury through a pathway involving TIMP‐1 and the FAK/Snail pathway

Pluripotent Stem Cell-derived Neuruloids - A New Approach to Developmental Analysis and Disease Modeling

Generation of PSC-derived neuruloids hopes to provide insight into human development and a range of poorly understood human genetic diseases and pediatric cancers

TIMP Proteins Inhibit PSC-derived Teratoma Formation

The ablation of proliferative pluripotent stem cells (PSCs) before or after the transplantation of PSC-derivatives would significantly reduce associated risks, including teratoma formation.


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