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ESCs/iPSCs

Gene Editing to Install a Safety Switch in iPSC

Researchers now describe the improved design and in vitro and in vivo testing of a novel inducible “suicide switch” safety system for iPSC‐derived cell‐based therapies

DNMT3B Controls Metabolic Flux of hESCs

A new study reveals a link between DNA methyltransferase 3B and metabolic flux in human embryonic stem cells

GABAergic Interneuron Generation from PSCs

A new article considers the progress and discusses the remaining challenges regarding the use of stem cell-derived cortical interneurons in the study and treatment of forebrain disease

E-cad Promotes the Primed Pluripotent State

Transition from the naïve to the primed state of pluripotency associates with the epithelial to mesenchymal transition (EMT) and a metabolic switch 

How Metabolism Impacts the Maturity of iPSC-derived Endothelial Cells

Lowering the intracellular pH can induce the maturation of endothelial cells derived from human induced pluripotent stem cells and hence enhance their regenerative potential

Stem Cell Platform for Evaluation of Nanoplastics

A plethora of plastic types, particle sizes, and a lack of reliable models combine to make the study of environmental plastic pollution on human health a challenging task. 

hiPSC-derived Cortical Neurons

Neuronal replacement by stem cell transplantation represents a potential therapy for neurodegenerative diseases. 

Single‐cell Analysis of RGC Development

Recent advances in single‐cell transcriptomics are paving the way for a comprehensive understanding of disease modeling in terms of cellular complexity and dysregulated genes/signaling pathways.

Replicates in Stem Cell Models

The routine differentiation of human pluripotent stem cells into a multitude of desired cell types has increased the complexity of the requirement for technical or biological replicates in stem cell‐based experimental studies.

Maturation in hiPSC‐derived Cardiac Muscle

Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) have enormous potential in the modeling of human cardiac function and disease; however, these cells are limited by their physiologic immaturity.

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