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Complex Disease Models from 3D Brain Organoids

A new review article stresses the importance of implementing complex 3D brain organoids derived from human induced pluripotent stem cells

New Study Describes the Formation of Embryo-like Entities from Pluripotent Stem Cells

An engineered morphogen signaling center within an embryonic stem cell aggregate supports the development of “embryoids” that exhibit germ layer development

Trpv4 Regulates iPSC Chondrogenesis

An improved understanding of the role of TRPV4 in chondrogenesis may provide insight into the development of new therapeutic approaches

Developing Stem Cell Therapies for Diabetes

A new article discusses the potential of stem cell-derived pancreatic progenitors and matured insulin-producing cells to treat diabetes

SARS-CoV-2, PSCs, and Organoids - A Review

A new review discusses the use of human pluripotent stem cell-derived cells and organoids in severe acute respiratory syndrome coronavirus 2 research

iBlastoids – The Future of Human Blastocyst Research?

New research reports on "iBlastoids" - blastocyst-like structures formed from iPSCs that model several aspects of human blastocyst biology

MGA Suppresses Meiosis-related Genes in mESCs

A new study uncovers the detailed molecular bases of PRC1.6 function in mouse embryonic stem cells through an evaluation of MGA activity

Naïve ESC-derived Human Blastoids as In-vitro Models of Human Blastocysts

Researchers report on naïve ESC-derived human "blastoids" and their applicability to the study of early human development, early pregnancy loss, and early developmental defects 

Induced Pluripotent Stem Cell-derived Neurons Provide Mechanistic Insight into Lysosomal Storage Disorder

An exploration of the links between glucosphingolipid accumulation and mTORC1 activity in human induced pluripotent stem cell‐derived neurons from neuronopathic Gaucher disease patients

Accurate and Reliable Generation of Human iPSCs For Disease Modeling and Clinical Applications

Reprogramming in the presence of CYCLIND1 overexpression allows for the more accurate and reliable generation of human iPSCs for disease modeling and clinical applications


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