ESCs/iPSCs

Researchers from the lab of Ton J.

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, leads to kidney failure in most patients. While mutations in the Polycystin 1 (PKD1) gene cause 85% of cases, we do not fully understand how dysregulation of PKD1 leads to cyst formation on a molecular level.

The four transcription factors that make up the Yamanaka “cocktail” (Oct4, Sox2, Klf4, and Myc, or OSKM) are well known for their capacity to reprogram somatic cells into induced pluripotent stem cells (iPSCs).

A recent STEM CELLS Translational Medicine article from the labs of

Making high‐quality dopamine‐producing cells for basic studies or small molecule screening remains critical to the development of novel therapeutics for ventral midbrain disorders. However, many ventral midbrain assays suffer from low signal to noise ratio thanks to low levels of dopamine and tyrosine hydroxylase, the rate‐limiting enzyme for dopamine synthesis.

Researchers report on a new age‐related macular degeneration model that more faithfully mimics the interaction of RPE and Bruch's membrane under disease conditions

Researchers report how a large intergenic non-coding RNA inhibits the early stage of mouse embryonic stem cell differentiation by regulating LIF/STAT3 signaling

While recent studies have demonstrated the generation of human pluripotent stem cell (PSC)-derived midbrain organoids that display structural and functional features of the midbrain, multiple issues currently hinder clinical translation.

Chemically-induced pluripotent stem cells generated from granulosa cells can differentiate into primordial-germ-cell-like cells and form oocytes that produce fertile mice

Modeling human neurodevelopmental disease using stem cell biology techniques requires significant expertise to allow for the discovery of cell phenotypes.