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ESCs/iPSCs

Increased pH Limits Formation of WPB in hiPSC-ECs

Researchers from the lab of Ton J.

Cyst Epithelial-derived iPSCs from ADPKD Patients

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, leads to kidney failure in most patients. While mutations in the Polycystin 1 (PKD1) gene cause 85% of cases, we do not fully understand how dysregulation of PKD1 leads to cyst formation on a molecular level.

OSKM Selectively Target Leukemia

The four transcription factors that make up the Yamanaka “cocktail” (Oct4, Sox2, Klf4, and Myc, or OSKM) are well known for their capacity to reprogram somatic cells into induced pluripotent stem cells (iPSCs).

iPSC-Derived Endothelial Cells to Treat Hemophilia

A recent STEM CELLS Translational Medicine article from the labs of

Increasing Dopamine Levels in Induced Ventral Midbrain Cells

Making high‐quality dopamine‐producing cells for basic studies or small molecule screening remains critical to the development of novel therapeutics for ventral midbrain disorders. However, many ventral midbrain assays suffer from low signal to noise ratio thanks to low levels of dopamine and tyrosine hydroxylase, the rate‐limiting enzyme for dopamine synthesis.

Patient-specific iPSCs Aid the Development of New Age-related Macular Degeneration Model

Researchers report on a new age‐related macular degeneration model that more faithfully mimics the interaction of RPE and Bruch's membrane under disease conditions

Deciphering the Role of Long Non-coding RNAs in ESC Differentiation

Researchers report how a large intergenic non-coding RNA inhibits the early stage of mouse embryonic stem cell differentiation by regulating LIF/STAT3 signaling

Midbrain Organoid Generation for PD Modeling

While recent studies have demonstrated the generation of human pluripotent stem cell (PSC)-derived midbrain organoids that display structural and functional features of the midbrain, multiple issues currently hinder clinical translation.

Granulosa Cells – The Key to Generating Functional Oocytes In Vitro?

Chemically-induced pluripotent stem cells generated from granulosa cells can differentiate into primordial-germ-cell-like cells and form oocytes that produce fertile mice

Neurodevelopmental Disease Modeling for Non‐stem Cell Biologists

Modeling human neurodevelopmental disease using stem cell biology techniques requires significant expertise to allow for the discovery of cell phenotypes.

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