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ESCs/iPSCs

iPSC Models of Glial Dysfunction

A new review summarizes advances in iPSC‐based modeling to explore glial cell involvement in neurodegenerative diseases

Disease-specific iPSC Model Highlights New Therapeutic Avenue for Vision Loss

iPSC-derived AMD model used to investigate the interplay between lysosome function and complement activation in the hope of identifying therapeutic targets

Deciphering the MicroRNA-mediated Control of Pluripotent Stem Cell Differentiation

The miR‐183/96/182 cluster controls retinal tissue morphogenesis and represents an important regulator of PAX6 expression

Boosting Cardiac Differentiation of ESCs via miR‐184/Wnt3 Pathway Modulation

Modulating the miR‐184/Wnt3 pathway in embryonic stem cells may provide for the development of efficient cell therapies for the damaged heart

The Mediator Complex – The Gateway to Naïve Pluripotency?

CDK8/19 Mediator components control pluripotent stem cell differentiation and self-renewal and regulate preimplantation naïve epiblast gene expression

Induction of Alveolar Type I Cells from iPSCs

Kanagaki et al. underscore the potential utility of iPSC-derived AT1cells in understanding their differentiation from AT2 cells in vitro.

Modeling Aortic Diseases Using iPSCs

A review summarizes in vitro models used in aortic disease research and provides guidance for the development of advanced models using iPSCs

Chromatin Accessibility in Canine Reprogramming

New research identifies differences in the global chromatin landscape that occur during the cellular reprogramming of canine cells

Ischemic Disease Therapy Using Human iPSCs

iPSC‐derived smooth muscle cells enhance iPSC‐derived endothelial cells' therapeutic efficacy in peripheral artery disease

hPSC-derived Beta Cells with Enhanced Function

Adding islet-associated environmental cues could represent a promising route to enhance the function of hPSC‐derived beta cells

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