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ESCs/iPSCs

Yap Isoforms Control ESC Self‐renewal and Differentiation

A new study describes the multifaceted and cell state‐dependent role of Yap isoforms in embryonic stem cell fate decision

Nodal Signaling in hPSCs

A new review discusses recent studies that have clarified the role of Nodal signaling in the maintenance and differentiation of human pluripotent stem cells

GPC4 Downregulation in iPSCs Promotes Differentiation into Dopaminergic Neurons that Rescue Parkinson's Disease Symptom

Researchers describe an alternative approach to the differentiation of human iPSCs into ventral midbrain dopaminergic neurons that can be used to treat Parkinson's disease

Fluid Shear Stress Promotes ESC Pluripotency

Fluid shear stress supports mouse embryonic stem cell pluripotency and obviates the need to add leukemia inhibitory factor to bioreactor culture

NT‐3 Treatment as a Novel Cell-free Therapeutic Approach for Myocardial Infarction-associated Injury

New research supports the use of Neurotrophin‐3 treatment as a novel cell-free therapeutic approach for myocardial infarction-associated injury

Identifying the Gene Regulatory Networks Controlling Efficient Human iPSC Chondrogenesis

Inhibiting the expression of specific WNTs and MITF during the chondrogenic differentiation of human iPSCs significantly increases chondrocyte homogeneity

Faster iPSC Generation May Allow Enhanced Disease Investigation and Therapeutic Screening

New study highlights synthetic mRNA-mediated differentiation of human iPSCs as the future of disease investigation and therapeutic screening

Exploring the Role of IGF1-IGFBP Interactions in Retinal Organoid Formation

IGF‐binding proteins enable the role of IGF1 in lamination and photoreceptor development in a stage‐specific manner within retinal organoids

Gene-modified Organoids Aid the Development of Retinal Degenerative Disease Therapies

Studies of NRL expression in retinal organoids may lead to the development of efficient transplantation therapies for retinal degenerative diseases

In vivo Analysis of Friedreich Ataxia iPSC‐derived Neurons

Researchers explore the transplantation of human iPSC-derived DRG sensory neurons into adult rodents as a possible treatment for peripheral neuropathies

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