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ESCs/iPSCs

Small-molecule Compound Promotes Function of Cells Carrying Mitochondrial Mutations

A small-molecule compound that activates mitochondrial respiration can rescue defects to neuronal differentiation in iPSCs carrying mutant mitochondrial DNA

Neurotrophin‐3 Protects Cardiovascular Progenitor Cells from I/R-Injury

Neurotrophin‐3 secreted from human ESC-derived cardiovascular progenitor cells may protect from  ischemia/reperfusion injury

Exploring the Immunogenicity of Human iPSC-derived Cells

While transplanted human iPSC-derived skeletal muscle cells become infiltrated by immune cells after transplantation, this does not negatively impact engraftment

iPSC-derived Heart-on-a-Chip System Takes Another Step Forward

A study reports a microfluidic “heart-on-a-chip” system and its validation via an analysis of responses to electrical stimulation and drug administration

GPC4 Regulates Neuronal Differentiation of iPSCs

GPC4 downregulation prompts efficient differentiation of iPSCs into dopaminergic neurons

Deciphering LIF-mediated ESC Pluripotency

JAK2 mediates the epigenetic control of pluripotency in mouse embryonic stem cells

iPSC-based Treatments for Sensorineural Hearing Loss

A new review highlights the significant achievements and challenges associated with iPSC‐based otic cell modeling

iPSC-derived Organoids Support the Study of Alveolar Cell Differentiation and Function

A new study confirms that alveolar type I cells present in induced pluripotent stem cell‐derived alveolar organoids closely resemble primary alveolar cells

Engineering, β‐cell function, and Diabetes

In vitro models of human β‐cells and insulin secretion as powerful tools to study diabetes

CRISPR Editing of GLI1 in Human ESCs

Reduced GLI1 expression in ESCs by gene-editing leads to differentiation defects

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