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Large Novel Cohort Highlights the Factors Influencing Human Reprogramming

Researchers discover that donor age, ancestry, and chromatin remodeling complex component expression significantly affect reprogramming efficiency

The Search for Small Molecule Inhibitors Uncovers an Unexpected Cardiomyogenesis Route

Researchers report the identification of small molecules that promote cardiomyogenesis through the TGFβ pathway and not the Wnt/β‐catenin pathway

Large-scale Generation of Light-Responsive Retinal Organoids for Drug Screening

An optimized differentiation strategy permits the large-scale production of retinal organoids that display light responsiveness and use in drug testing

Glycoproteomic Analysis Reveals New Pluripotency-associated Cell Surface Marker

Researchers discover a new cell surface glycoprotein that plays a crucial role in the stemness and proliferation of human embryonic stem cells

 

Beat that! – Human ESC-derived Cardiomyocytes Restore Cardiac Function in Monkeys

New findings establish the transplantation of embryonic stem cell-derived cardiomyocytes as an effective means to restore lost cardiac function in monkeys

Partial Reprogramming in vivo Enhances Wound Repair in Mice

New research establishes how partial reprogramming may be harnessed to promote wound healing by reducing skin fibrosis and scar formation

p53 DNA Damage Response Causes Concern for CRISPR–Cas9 Genome Editing

Two new studies in immortalized retinal pigment epithelial cells and induced pluripotent stem cells raise more concern regarding CRISPR-Cas9-based genome editing safety

Organ-on-Chip Stem Cell Coculture Provides Boost for Study of Motor Neuron Disease

A new study demonstrates how three-dimensional coculture of induced pluripotent stem cell-derived spinal motor neurons enhances both cell maturity and functionality

Small Molecules boost Cpf1-mediated Genome Editing in Pluripotent Stem Cells

Chinese researchers discover of two small molecule compounds that enhance CRISPR-Cpf1-based genome engineering of human pluripotent stem cells

New iPSC-model of Alzheimer's Disease Points to Viable Therapeutic Approaches

Researchers describing a novel induced-pluripotent stem cell model of ApoE4-related Alzheimer's disease highlight potentially exciting new treatment approaches

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