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Deriving Clinically-Relevant Numbers of Human iPSCs From Optimized Bioreactor Culture

An optimized protocol employing a vertical‐wheel bioreactor achieves the rapid generation of clinically-relevant numbers of human induced pluripotent stem cells

PAX6-targeted miRNA in Human Retinal Organoids

Peskova et al. provide evidence that the miR‐183/96/182 cluster plays a significant role in the morphogenesis of the neural retina

Immunogenicity Of iPSC-derived Myogenic Cells

Analysis of humanized mouse models provided evidence that human immune cell infiltration in skeletal muscle should not be used alone to predict immunogenicity

iPSC for Neurodevelopmental Disorders

researchers review current knowledge regarding iPSC models for schizophrenia and autism spectrum disorders with an emphasis on their discrimination.

YAP Regulates Cartilage Formation from iPSCs

A laminin-based culture substrate causes poor chondrogenesis from hiPSCs, while the inactivation of YAP promotes a round cell morphology and improves cartilage formation

Donor Genetic Traits Impact Stem Cell Heterogeneity

A new review discusses the roles played by donor genetic traits in the functional heterogeneity of stem cells and their implications for regenerative medicine and therapy

Cp40 Reverses Pathology in AMD-RPE

The modulation of the complement system may represent a useful therapeutic approach for AMD cases associated with complement dysregulation.

Adjuvant Therapy for Cardiac Cell Transplantation

sEHIs results in a significant increase in the retention of transplanted cells and an improvement in cardiac function 

Accelerated Neural Differentiation of hPSCs

A new study removes a historical bottleneck that has hindered improvement to the control and speed of generating neural cells from hPSCs.

Perspective on Cardiac Application Of hPSCs

The ability to generate multiple cardiac cell types from human pluripotent stem cells will provide researchers with the means to evaluate their application in the repair of damaged myocardium.


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