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ESCs/iPSCs

iBlastoids – The Future of Human Blastocyst Research?

New research reports on "iBlastoids" - blastocyst-like structures formed from iPSCs that model several aspects of human blastocyst biology

MGA Suppresses Meiosis-related Genes in mESCs

A new study uncovers the detailed molecular bases of PRC1.6 function in mouse embryonic stem cells through an evaluation of MGA activity

Naïve ESC-derived Human Blastoids as In-vitro Models of Human Blastocysts

Researchers report on naïve ESC-derived human "blastoids" and their applicability to the study of early human development, early pregnancy loss, and early developmental defects 

Induced Pluripotent Stem Cell-derived Neurons Provide Mechanistic Insight into Lysosomal Storage Disorder

An exploration of the links between glucosphingolipid accumulation and mTORC1 activity in human induced pluripotent stem cell‐derived neurons from neuronopathic Gaucher disease patients

Accurate and Reliable Generation of Human iPSCs For Disease Modeling and Clinical Applications

Reprogramming in the presence of CYCLIND1 overexpression allows for the more accurate and reliable generation of human iPSCs for disease modeling and clinical applications

Microfluidics and Autologous Cell Replacement

A review article discusses the application of state-of-the-art microfluidic devices to stem cell transfection and post-differentiation cell enrichment

iPSC-model of SARS-CoV-2 Upper Airway Infection

Researchers describe the development of an induced pluripotent stem cell-derived model of SARS-CoV-2 infection/replication in the upper airways

Zbtb46 Induces ESC-derived Hematopoietic Progenitors

Researchers probe the function of Zbtb46 in embryonic stem cell-derived blood cell progenitors using chemically inducible transgenic cell lines

JAK2-mediated Epigenetic Alterations Support the Pluripotency of Mouse ESCs

JAK2 plays a novel epigenetic regulatory role that supports the maintenance of the pluripotent state of mouse embryonic stem cells

Yap Isoforms Control ESC Self‐renewal and Differentiation

A new study describes the multifaceted and cell state‐dependent role of Yap isoforms in embryonic stem cell fate decision

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