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Describing the Barriers to the Totipotent State of ESCs

New research describes CTCF as a significant barrier to the conversion of mouse embryonic stem cells into a two cell-like totipotent state 

hiPSC-Derived Glial-enriched Progenitor Therapy for White Matter Stroke

Glial-enriched progenitors derived from human iPSCs may form a novel cell therapy for white matter stroke and related neurodegenerative diseases 

How Orphan Motifs Impact Gene Expression in Pluripotent Stem Cells

A fascinating new study describes how orphan motifs may impact gene expression in cells such as pluripotent stem cells

Reviewing Megakaryocytes and Platelet Heterogeneity

A review summarizes current findings regarding the functional/developmental heterogeneity of megakaryocytes and potential links to platelet heterogeneity

Deciphering the Zbtb46-mediated Control of Hematopoietic Development

Zbtb46 expression during ESC differentiation suppresses myeloid development and diverts mesoderm cells toward erythroid development

Pericytes within Assembloid Model Supports Study of SARS‑CoV‑2 Infection

Pericyte-like cell-containing cortical organoids support SARS-CoV-2 infection and may represent an exciting new platform for related studies

BRD4-mediated Regulation of Pluripotency

A new review discusses the central role of BRD4 in stem cell identity and potential applications of BRD4 inhibitors in stem cell-based therapeutics

Overcoming Reprogramming Induced Senescence

A newly discovered mechanism overrides reprogramming-induced senescence, thereby increasing the number of cells amenable to becoming iPSCs

ROS Levels Control PSC Proliferation

Maintaining physiological levels of ROS is essential for proliferation and accurate DNA synthesis in pluripotent stem cells

Fighting Fibrosis with iPSC-derived Macrophages

Researchers demonstrate the ability to efficiently derive macrophages from human iPSCs with the ability to improve liver fibrosis in a mouse xenograft model


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