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Reviewing Aged Stem Cell Restoration

Researchers led by Isabel Beerman (NIH, Baltimore, Maryland, USA) discuss the current status of interventions to improve stem cell aging phenot

Cxcr5 Regulates Neurogenesis in the Aged Brain

Results of a new study from researchers led by Henrik Ahlenius (Lund University, Lund, Sweden) now establish how infl

Proteasome Activation Mediates Exercise-Elicited Hippocampal Neurogenesis

A new study from the laboratories of Wulin Yang (Chinese Academy of Sciences, Hefei, China) and Li Lu (Shanxi University, Taiyuan,

New Model Confirms Gut-to-Brain Propagation of Parkinson’s Disease

Researchers confirm that α-synuclein can pass from the gut to the brain via the vagus nerve to induce Parkinson’s-like symptoms using a new mouse model

Retrotransposon Mediated “Inflammaging” – A Target for The Treatment of Age-associated Disorders?

Activation of retrotransposons contributes to inflammaging, although the L1 reverse transcriptase represents a target for age-associated disorder treatment

Eliminating Senescent Cells as a New Approach to Neurodegenerative Disease Treatment

Researchers highlight the potential for the pharmacological targeting of senescent glial cells as an effective treatment for cognition-associated neuronal loss

Linking SIRT6 Loss to Developmental Retardation in Non-Human Primates

A new developmental analysis in primates suggests that the SIRT6 stress-responsive protein deacetylase may represent a pro-longevity factor in humans

Reversing Signs of Aging via Splicing with Reversalogues

A new study suggests that resveratrol-like compounds that can target multiple mRNA splicing factors may reverse the signs of cellular aging

Inhibiting Age-related Bone Loss by Eliminating Senescent Cells

The clearance of senescent cells in old mice reverses age-related bone loss and may represent an exciting new anti-aging therapy in human patients

TIMP2: The Key to Revitalizing the Aging Brain?

Researchers assessing the rejuvenating potential of human cord blood uncover a key role for the Tissue inhibitor of metalloproteinases 2 (TIMP2) protein


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