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Aging

Restoring Youthful Immune Function Through Metabolic Reprogramming Reverses Cognitive Aging

Research focused on prostaglandin E2 reveals that the restoration of a youthful immune function through metabolic reprogramming can reverse cognitive aging

Unlocking the mystery behind skeletal aging

LOS ANGELES, CA (US), February 2021 — Researchers from the University of California Los Angeles School of Dentistry have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide.

Study reveals how longevity gene protects brain stem cells from stress

NEW YORK, NY (US), February 2021 — A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators.

Reviewing Aged Stem Cell Restoration

Researchers led by Isabel Beerman (NIH, Baltimore, Maryland, USA) discuss the current status of interventions to improve stem cell aging phenot

Cxcr5 Regulates Neurogenesis in the Aged Brain

Results of a new study from researchers led by Henrik Ahlenius (Lund University, Lund, Sweden) now establish how infl

Proteasome Activation Mediates Exercise-Elicited Hippocampal Neurogenesis

A new study from the laboratories of Wulin Yang (Chinese Academy of Sciences, Hefei, China) and Li Lu (Shanxi University, Taiyuan,

New Model Confirms Gut-to-Brain Propagation of Parkinson’s Disease

Researchers confirm that α-synuclein can pass from the gut to the brain via the vagus nerve to induce Parkinson’s-like symptoms using a new mouse model

Retrotransposon Mediated “Inflammaging” – A Target for The Treatment of Age-associated Disorders?

Activation of retrotransposons contributes to inflammaging, although the L1 reverse transcriptase represents a target for age-associated disorder treatment

Eliminating Senescent Cells as a New Approach to Neurodegenerative Disease Treatment

Researchers highlight the potential for the pharmacological targeting of senescent glial cells as an effective treatment for cognition-associated neuronal loss

Linking SIRT6 Loss to Developmental Retardation in Non-Human Primates

A new developmental analysis in primates suggests that the SIRT6 stress-responsive protein deacetylase may represent a pro-longevity factor in humans

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