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Aging

Retrotransposon Mediated “Inflammaging” – A Target for The Treatment of Age-associated Disorders?

Activation of retrotransposons contributes to inflammaging, although the L1 reverse transcriptase represents a target for age-associated disorder treatment

Eliminating Senescent Cells as a New Approach to Neurodegenerative Disease Treatment

Researchers highlight the potential for the pharmacological targeting of senescent glial cells as an effective treatment for cognition-associated neuronal loss

Linking SIRT6 Loss to Developmental Retardation in Non-Human Primates

A new developmental analysis in primates suggests that the SIRT6 stress-responsive protein deacetylase may represent a pro-longevity factor in humans

Reversing Signs of Aging via Splicing with Reversalogues

A new study suggests that resveratrol-like compounds that can target multiple mRNA splicing factors may reverse the signs of cellular aging

Inhibiting Age-related Bone Loss by Eliminating Senescent Cells

The clearance of senescent cells in old mice reverses age-related bone loss and may represent an exciting new anti-aging therapy in human patients

TIMP2: The Key to Revitalizing the Aging Brain?

Researchers assessing the rejuvenating potential of human cord blood uncover a key role for the Tissue inhibitor of metalloproteinases 2 (TIMP2) protein

NAD+: A new Strategy to Combat Human Aging?

A new study shows that boosting NAD+ levels can reduce the signs of aging in mice and may also be effective in humans

Pomegranate-derived Compound Reverses Signs of Aging in Mice

A new study finds that a pomegranate-derived compound may be represent an effective means to fight the aging process

Augmenting NAD+ to Treat Age-related Degenerative Diseases?

Researchers discover that repletion of nicotinamide adenine dinucleotide (NAD+) may be an effective means to treat age-related degenerative disease

Somatic Role for the Oct4 Pluripotency Gene Described

Researchers find that the somatic expression of the Oct4 pluripotency gene is linked to the function of smooth muscle cells and the resolution of atherosclerotic plaques

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