Skeletal muscle decellularization allows the generation of natural scaffolds that retain the extracellular matrix mechanical integrity, biological activity, and three‐dimensional (3D) architecture of the native tissue.
Interpretation of observed change in a continuous outcome measure as preliminary evidence of efficacy in the setting of an uncontrolled trial can lead to erroneous conclusions due to the effect of regression to the mean.
Adoptive cell therapy (ACT) as an approach to cancer treatment involves the administration of antitumor immune cells to target residual disease in patients after completion of chemo/radiotherapy. Currently, the identification and generation of antitumor effector cells that efficiently recognize tumor cells remain important barriers to the success of ACT in cancer clinical trials.
The promotion of blood vessel growth for therapeutic purposes remains a challenge both for the treatment of ischemia and the generation of functional tissue‐engineered grafts, as physiological angiogenesis represents an extraordinarily complex process.
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