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CRISPR-activation of SOX2 Promotes Corneal Endothelial Cell-mediated Wound Healing and Regeneration

New research describes how CRISPR-activation of SOX2 gene expression can enhance wound healing of the corneal endothelium and inhibit vision loss

Novel 3D Bioprinting Approach Generates Vascularized and Well-organized Cardiac Tissue Constructs

Advanced bioprinting technique employing iPSC-derived cardiomyocytes and endothelial cells generates cardiac tissue constructs with improved functionality

CRISPR/Cas9-based Exon Skipping Returns Dystrophin Expression to a Canine Model of DMD

Studies in an animal model of Duchenne muscular dystrophy highlight the in vivo utility of CRISPR/Cas9-based exon “skipping”-based treatment approaches

Homing CRISPR/Cas9 Technology to Barcode and Lineage Trace Mouse Development

A new CRISPR/Cas9 barcoding approach permits reconstruction of early mouse lineages and investigation of brain axis development

CRISPR Activation Strategy Takes Induced Pluripotent Stem Cell Generation to another Level

Targeting an embryo genome-activation motif permits the first generation of induced pluripotent stem cells via CRISPR activation of reprogramming factors

Three-Dimensional Bioprinting: The Future of Corneal Blindness Treatment?

Researchers employ pneumatic 3D extrusion bioprinting to generate bona fide biological corneal structures for regenerative medicine applications

CRISPR/Cas9-mediated in vivo Epigenetic Remodeling: A New Means to Treat Disease?

Researchers describe the application of CRISPR/Cas9-mediated epigenetic remodeling to treat kidney injury, diabetes, and muscular dystrophy in vivo

Computerized Colony Selection Promises to Increase iPSC Generation Efficiency

A new computerized technique based on morphological assessments may lead to increases in the efficiency of induced pluripotent stem cell reprogramming strategies 

Nanowarming Provides Big Results for Transplant Patients

A new nanoparticle-based technique for rewarming cryopreserved tissues may revolutionize the field of organ transplants

Creating Bioartificial Limb Replacements - Give us a hand!

Researchers describe the generation and transplantation of the first bioartificial complex limb graft via the repopulation of an extracellular matrix scaffold

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