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Killers at The Crossroads

Adoptive cell therapy (ACT) as an approach to cancer treatment involves the administration of antitumor immune cells to target residual disease in patients after completion of chemo/radiotherapy. Currently, the identification and generation of antitumor effector cells that efficiently recognize tumor cells remain important barriers to the success of ACT in cancer clinical trials.

Can Targeting Cardiomyocyte Metabolism Improve Cardiac Regeneration?

Inhibiting fatty-acid utilization can reduce the reactive oxygen species-mediated DNA damage response and promote cardiomyocyte proliferation in the postnatal mouse heart

Single Cell Analyses Suggest Stressed out Organoids Do Not Match Up

A comparison of the transcriptomes of the developing human cortex and cortical organoids at the single-cell level provide evidence for stress-mediated differences

Alveolar War - The Rise of In Vitro Alveolar Models

Over the last decade, stem cell‐derived culture models of human lungs have garnered renewed interest as a means to recapitulate human lung tissues in a dish.

The Vision of the Regenerative Medicine Manufacturing Society

The Regenerative Medicine Manufacturing Society recently provided a Perspective article in

Vascularization for Regenerative Medicine – A Review

The promotion of blood vessel growth for therapeutic purposes remains a challenge both for the treatment of ischemia and the generation of functional tissue‐engineered grafts, as physiological angiogenesis represents an extraordinarily complex process.

Toxicity in Cartilage Biofabrication

Three‐dimensional biofabrication using photo‐cross-linkable hydrogel bioscaffolds may revolutionize the need for transplants and implants in joints, with articular cartilage being an early target tissue.

Prenatal Stem Cell Therapy - A Concise Review

A new review article from the laboratory of Åsa Ekblad‐Nordberg (Karolinska Institutet, Stockholm, Sweden) provides a summary of the past, the present progress, and the future potential of prenatal stem cell therapy.

Directly Programmed Neurons Provide Boost for Chemotherapy‐induced Neuropathy Research

The efficient generation of induced sensory neurons provides a new means to discover novel treatments for chemotherapy-induced peripheral neuropathy

Tracing Cell Lineages in hPSCs with Cre Reporter

While human pluripotent stem cells (hPSCs) provide an unprecedented opportunity to investigate human development and the relationship between gene regulation and differentiation, we currently lack a stable hPSC reporter line available for non-invasive fate mapping.

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