Direct reprogramming platform represents a new model for investigating neuronal maturation and screening neuronal maturation modifiers for the treatment of Huntington's disease patients
The loss or damage of auditory neurons can lead to sensorineural hearing loss and deafness, and treatments such as amplification and cochlear implants rely on surviving neurons to convey auditory signals to the brain. Regeneration strategies that focus on endogenous cell therapy may permit the replacement of lost neurons to restore the auditory circuit.
Researchers describe how Insulin‐like growth factor binding protein‐7 can prompt the transdifferentiation of fibroblasts into osteoblasts that can form ectopic bone
Cell therapy in bone tissue engineering has considerable translational potential; however, the limited harvest of osteoblasts and mesenchymal stem cells, and a poor osteogenic potential of isolated patient fibroblasts constrain current approaches.