The loss or damage of auditory neurons can lead to sensorineural hearing loss and deafness, and treatments such as amplification and cochlear implants rely on surviving neurons to convey auditory signals to the brain. Regeneration strategies that focus on endogenous cell therapy may permit the replacement of lost neurons to restore the auditory circuit.
Cell therapy in bone tissue engineering has considerable translational potential; however, the limited harvest of osteoblasts and mesenchymal stem cells, and a poor osteogenic potential of isolated patient fibroblasts constrain current approaches.
While previous reports demonstrated that human sensory neurons could be directly converted from primitive CD34+ hematopoietic cells, the small scale and derivation from less abundant allogenic sources of cord or drug mobilized peripheral blood represented problems.
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