Direct Reprogramming

Direct reprogramming platform represents a new model for investigating neuronal maturation and screening neuronal maturation modifiers for the treatment of Huntington's disease patients

A newly developed tool automatically identifies those small molecules that enhance cell reprogramming from one fate into another

The induction of neurogenic properties in mammalian Müller glia could prompt the development of advanced retinal regeneration strategies

Direct reprogramming of patient-derived cells described as a novel platform to screen for new targets for the treatment of Huntington's disease

Studies of pancreatic α-cell to β-cell-conversion in transgenic mouse models suggest targeting DNA methylation as a possible treatment for diabetes

TransSynW is established as a fundamental tool to guide the design of novel cell conversion protocols in stem cell research and regenerative medicine

A small molecule cocktail can induce the transformation of fibroblasts into rod photoreceptor-like cells with the potential to restore vision loss

The loss or damage of auditory neurons can lead to sensorineural hearing loss and deafness, and treatments such as amplification and cochlear implants rely on surviving neurons to convey auditory signals to the brain. Regeneration strategies that focus on endogenous cell therapy may permit the replacement of lost neurons to restore the auditory circuit.

Researchers describe how Insulin‐like growth factor binding protein‐7 can prompt the transdifferentiation of fibroblasts into osteoblasts that can form ectopic bone

Cell therapy in bone tissue engineering has considerable translational potential; however, the limited harvest of osteoblasts and mesenchymal stem cells, and a poor osteogenic potential of isolated patient fibroblasts constrain current approaches.