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Adult Stem Cells

Studying Neuronal Network Formation in Dissociated Cerebral Organoid Cultures

Researchers employ human cerebral organoids to evaluate patterns of neural network activity to investigate the functionality of human neuronal networks

 

Role of FRα in Glial De-differentiation

Previous research from the lab of Chandra Shekhar Mayanil (Stanley Manne Children's Research Institute, Chicago, IL, USA) established that Folate Receptor-α (FRα) translocates to the nucleus and upregulates the transcription of pluripotency-associated genes.

Engineered Stem Cells for Targeted Cancer Therapy

Multiple stem cell types exhibit inherent cancer tropism, while engineered stem cells have been used as therapeutic agents to specifically target cancer cells. More recently, stem cells engineering has been employed to target multiple surface‐receptors on tumor cells, as well as endothelial and immune cells of the tumor microenvironment.

Xeno-free Culture Reagents Improves Bone Generation by Periosteum‐derived Stem Cells

Replacing FBS with HPL increases the expansion efficiency and bone-forming capacity of hPDCs grown in microcarrier‐containing bioreactor culture

Adult Neurogenesis Detected in the Aged and Disease Human Brain

New study establishes neurogenesis in the hippocampi of elderly human brains and in brains of patients with mild cognitive impairments and Alzheimer’s disease

Pro‐Resolving Lipid Mediators and Receptors in Stem Cells

A recent STEM CELLS Translational Medicine review article from the laboratory of Mario Romano (University of Chieti‐Pescara, Italy) summarizes our current knowledge on specialized pro‐resolving lipid mediators (SPMs) in stem cells, with a special focus

Criteria to Define Salivary Gland Stem Cells

Researchers from the laboratory of Catherine Ovitt (University of Rochester, New York, USA) realized that several diverse and non‐overlapping cell

Reviewing the Mechanisms of Injury-induced Enteric Neurogenesis

A recent review article from the labs of Raleigh Jonscher (University of Colorado School of Medicine, USA) and Jaime Belkind‐Gerson (Children's Hospital Colorado, USA) offers a concise but wide‐ranging survey on the current state of progress in research related to a

Receptor-dependent Hedgehog Signaling in the Epithelial Stem Cell Niche

To investigate how Hedgehog signaling regulates the epithelial stem cell niche and controls stem cell differentiation within the cervical loop (a specific epithelial structure at the apical side of the tooth germ), researchers from the lab of

Induced Autophagy in Cartilage Endplate Stem Cells May Inhibit Intervertebral Disc Degeneration

Autophagy in cartilage endplate stem cells protects from inflammation‐induced cartilage degeneration and may inhibit intervertebral disc degeneration

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