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Adult Stem Cells

Deciphering How Stress Influences Stem Cells and Tissue Regeneration

A study establishes that stressed mice suffer from the loss of melanocyte stem cells and the appearance of har greying, showing how physiological status can affect tissue regeneration

Expanding Inner Ear Progenitor Cells

The impact of extracellular matrix mechanical cues and mechanotransduction signaling on inner ear progenitor cell (IEPCs) fate remains relatively undescribed; however, researchers led by

Bone Marrow Mononuclear Cells for Ischemic Stroke

Researchers led by Sean I.

Capillary-Resident EphA7-Positive Multipotent Pericytes

A current lack of markers for multipotent pericytes limits our understanding of their pathophysiological roles; however, researchers from the lab of Jun-ichi Kawabe (Asahikawa Medical University, Hokkaido, Japan) have now described how the implementation of EphA7 (Eph Receptor A7)  as a  marker to isolate pericytes from the microvessels of mouse subcutaneous adipose tissues. Yoshida et al.

Studying Neuronal Network Formation in Dissociated Cerebral Organoid Cultures

Researchers employ human cerebral organoids to evaluate patterns of neural network activity to investigate the functionality of human neuronal networks

 

Role of FRα in Glial De-differentiation

Previous research from the lab of Chandra Shekhar Mayanil (Stanley Manne Children's Research Institute, Chicago, IL, USA) established that Folate Receptor-α (FRα) translocates to the nucleus and upregulates the transcription of pluripotency-associated genes.

Engineered Stem Cells for Targeted Cancer Therapy

Multiple stem cell types exhibit inherent cancer tropism, while engineered stem cells have been used as therapeutic agents to specifically target cancer cells. More recently, stem cells engineering has been employed to target multiple surface‐receptors on tumor cells, as well as endothelial and immune cells of the tumor microenvironment.

Xeno-free Culture Reagents Improves Bone Generation by Periosteum‐derived Stem Cells

Replacing FBS with HPL increases the expansion efficiency and bone-forming capacity of hPDCs grown in microcarrier‐containing bioreactor culture

Adult Neurogenesis Detected in the Aged and Disease Human Brain

New study establishes neurogenesis in the hippocampi of elderly human brains and in brains of patients with mild cognitive impairments and Alzheimer’s disease

Pro‐Resolving Lipid Mediators and Receptors in Stem Cells

A recent STEM CELLS Translational Medicine review article from the laboratory of Mario Romano (University of Chieti‐Pescara, Italy) summarizes our current knowledge on specialized pro‐resolving lipid mediators (SPMs) in stem cells, with a special focus

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