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Cardiac Stem Cells

Decoding the Secretome of Cardiopoietic Cells

Researchers report the decoding of the secretome of clinical trial-biobanked cardiopoietic cells and link innate secretome traits with therapeutic outcomes

MMP9 Induces Cardiac Stem Cell Differentiation

Intracellular MMP9 expression aids the differentiation of human cardiac stem cells via epigenetic modifications and autophagy

Epicardial-mediated Regeneration

A new review discusses the prospects for reinstating full embryonic potential in the adult epicardium to facilitate cardiac regeneration

Metabolic Alterations and Cardiac Cell Function

Neonatal cardiac tissue stem‐like cells express metabolism-related genes that increase functional properties

Exosomes in Cardiac Protection and Repair

A recent review article discusses the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease

Trajectory Mapping of ESC Cardiogenesis

Despite the considerable interest in defining the transcriptional profiles of human cardiac cells at single‐cell resolution, data regarding the transient stages of early human cardiac progenitor cell development have remained elusive.

CRISPR Screen Highlights ZIC2 as an Essential Gene for Human Cardiogenesis

New research highlights the zinc-finger of the cerebellum 2 (ZIC2) gene as an essential factor in the formation of human cardiac progenitor cells from embryonic stem cells

Can Systems Proteomics Boost Cardiopoietic Stem Cell Therapy Translation?

A study reveals proteome remodeling within the infarcted heart and establishes that cardiopoietic stem cell therapy can reverse disease-associated proteomic changes

ZIC2 Controls the Emergence of Human Heart Progenitors

To reveal the regulators that control the formation of human cardiac progenitor cells without bias, researchers led by Kenneth R.

New Mechanism Behind Stem Cell Therapy in the Damaged Heart Uncovered

A fascinating new study suggests that stem cell therapy induces an acute inflammatory-based wound-healing response that rejuvenates the infarcted area of the heart

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