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Amniotic Stem Cells

Enhanced Large Animal Wound Healing with Amnion-based Therapeutics

Positive outcomes observed in a large animal model provide evidence for the translational value of amnion membrane-derived treatments for wound treatment

Fetal Precursor Cells in Gestational Diabetes

Research efforts have suggested that signatures of metabolic deregulation remain in cells early in development and, given their location on the inner side of the placenta, amniotic membrane stem cells may represent an indicator of how the intrauterine environment impacts the fetus.

Long-term Outcomes of hAECS for BPD

Previous research from the lab of Atul Malhotra (Monash University, Clayton, Victoria, Australia) reported on the immediate safety and neonat

A Step Towards the Treatment of Hematopoietic Disease with Amniotic Fluid Stem Cells

Researchers describes a means to expand HFSCs that engraft after intravascular administration in an autologous-like murine model of in-utero transplantation

In Utero hAFSCs Protect Spinal Cord from MMC

Researchers from the lab of Daigo Ochiai (Keio University School of Medicine, Tokyo, Japan) recently investigated the therapeutic effects and mechanisms of human amniotic fluid stem cell (hAFSC)‐based treatment for fetal myelomeningocele (MMC), due to its poor diagnosis and lack of prenatal treatments.

In Utero Transplantation of Amniotic Fluid Stem Cells

The in-utero transplantation of hematopoietic stem cells for the prenatal treatment of congenital hematological diseases suffers from sub‐therapeutic levels of long‐term hematopoietic engraftment.

Cell-Free Amniotic Membrane-derived Hydrogel Boosts Skin Wound Healing

By combining solubilized amniotic membrane into an easy to store and apply hydrogel, researchers have developed a cell-free means to accelerate wound healing

Identifying Stem Cell Factors which Repair the Heart

Researchers identify factors excreted from stem cells derived from the amniotic membrane of human placenta which aid cardiac repair.

Amniotic Fluid Stem Cells Aid Kidney Transplantation in Porcine Model

Mesenchymal stem cells derived from amniotic fluid are shown to protect against kidney fibrosis following transplantation in a pre-clinical model

Bioprinted Amniotic Stem Cells Aid Wound Repair

"Bioprinted Amniotic Fluid-Derived Stem Cells Accelerate Healing of Large Skin Wounds"

Current therapies for skin injuries such a serious burns rely on autologous skin grafts; a therapy which is limiting with regards to the number and size of donor sites, allografts; which suffer from the problem of immune rejection, the more recently developed non-cellular dermal substitutes; which are expensive and not cosmetically advantageous or lastly complex biological skin equivalents; which again suffers from pricing and immune rejection problems. However some recent developments show great promise, such as cell spraying and bioprinting technologies which allow for the deposition of cells and biomaterials into precise three-dimensional geometries in order to create anatomically correct structures. Mesenchymal stem cells (MSCs) are considered an attractive cell for use in such techniques due to their therapeutic potential for repair and regeneration of tissues damaged by injury or disease (Maxson et al. and Wang et al.), as are amniotic fluid-derived stem (AFS) cells due to their high proliferation capacity, multipotency, immunomodulatory activity, and lack of significant immunogenicity (De Coppi et al. and Moorefield et al.). In a recent study in Stem Cells Translational Medicine researchers from the laboratory of Shay Sokera at the Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA have shown that while MSCs and AFS cells both function well in wound closure and re-epithelialisation, AFS cells function better partly through increased secretion of trophic factors (Skardala and Macka et al.).

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