Cancer Stem Cells

Recent research highlighting the critical role of the tumor microenvironment in triple‐negative breast cancer (TNBC) development prompted researchers from the lab of Antoine E. Karnoub (Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA) to investigate the interaction of mesenchymal stem cells with TNBC cells.

Characteristics of the tumor microenvironment can inhibit CHD7 expression in glioblastoma tumor-initiating cells and prompt a pro-angiogenic response

Researchers show how the inhibition of a DNA repair mediator may represent an exciting means to potentiate chemotherapy in colorectal cancer patients 

Researchers chromatin remodeler expression in glioblastoma multiforme discover how BRG1 maintains cancer stem cell-identity and represents a therapeutic target

Researchers demonstrate that epigenetic silencing of TAP genes in breast cancer stem cells play a crucial role in immune evasion mechanisms

A new three-dimensional in vitro model of liver tumorigenesis may provide an efficient means to study cancer development and create new and effective therapies.

A new study suggests that dedifferentiated mature melanocytes represent the cell of origin for melanoma, and not stem cells as previously thought

A new study into colorectal cancer suggests that targeting FBXW7 may increase the sensitivity of cancer stem cells to commonly employed chemotherapeutics

A new study describes how hypoxia induces stem-like characteristics in brain tumor cells through the modulation of the chromatin environment of pluripotency-associated genes   

A new study of multiple adult stem cell types points to new hypothesis concerning differing cancer prevalence rates