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Cancer Stem Cells

LINC01133 Promotes CSC-like Traits in TNBC

Recent research highlighting the critical role of the tumor microenvironment in triple‐negative breast cancer (TNBC) development prompted researchers from the lab of Antoine E. Karnoub (Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA) to investigate the interaction of mesenchymal stem cells with TNBC cells.

Chromodomain Helicase DNA‐binding Protein 7 - A new Target for the Treatment of Glioblastoma?

Characteristics of the tumor microenvironment can inhibit CHD7 expression in glioblastoma tumor-initiating cells and prompt a pro-angiogenic response

New Cancer Treatment Combination Takes Down Patient-derived Colorectal Cancer Initiating Cells

Researchers show how the inhibition of a DNA repair mediator may represent an exciting means to potentiate chemotherapy in colorectal cancer patients 

BRG1 Chromatin Remodeler: A New Target for the Treatment of Highly Aggressive and Malignant Brain Tumors?

Researchers chromatin remodeler expression in glioblastoma multiforme discover how BRG1 maintains cancer stem cell-identity and represents a therapeutic target

TAP1: The Key to Immune Evasion by Breast Cancer Stem Cells?

Researchers demonstrate that epigenetic silencing of TAP genes in breast cancer stem cells play a crucial role in immune evasion mechanisms

Accelerating Liver Cancer Research with Three Dimensional Tumoroids

A new three-dimensional in vitro model of liver tumorigenesis may provide an efficient means to study cancer development and create new and effective therapies.

New Model Highlights a Mature Cell of Origin for Melanoma

A new study suggests that dedifferentiated mature melanocytes represent the cell of origin for melanoma, and not stem cells as previously thought

Cancer Stem Cell Study Uncovers Potential Means to Improve Disease Treatment

A new study into colorectal cancer suggests that targeting FBXW7 may increase the sensitivity of cancer stem cells to commonly employed chemotherapeutics

Tet1 and 3: New Targets in the Battle against Invasive and Heterogeneous Brain Tumors?

A new study describes how hypoxia induces stem-like characteristics in brain tumor cells through the modulation of the chromatin environment of pluripotency-associated genes   

Adult Stem Cells and Organoids Combine to Explore the Contribution of Cancer Risk Factors

A new study of multiple adult stem cell types points to new hypothesis concerning differing cancer prevalence rates

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