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Cancer Stem Cells

TRIM Proteins and Cancer Cell Stemness

The tripartite‐motif (TRIM) family of proteins participate in a variety of cellular functions and biological processes, and recent data has revealed their significant role in the acquisition and maintenance of the stem cell phenotype.

Delineating Tcf7l1-mediated Liver Cancer Stem Cell Regulation

A new study provides insight into the extracellular signals that modulate liver CSC self‐renewal and highlights the inhibitory roles of Tcf7l1 in cancer

Targeting Cancer Stem Cells Via Lipid Metabolism

A recent STEM CELLS review article from the laboratory of

Tcf7l1 Suppresses Liver CSC Self-renewal

A STEM CELLS study from the group of Yuanliang Wang and Cheng Qian (Chongqing

LINC01133 Promotes CSC-like Traits in TNBC

Recent research highlighting the critical role of the tumor microenvironment in triple‐negative breast cancer (TNBC) development prompted researchers from the lab of Antoine E. Karnoub (Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA) to investigate the interaction of mesenchymal stem cells with TNBC cells.

Chromodomain Helicase DNA‐binding Protein 7 - A new Target for the Treatment of Glioblastoma?

Characteristics of the tumor microenvironment can inhibit CHD7 expression in glioblastoma tumor-initiating cells and prompt a pro-angiogenic response

New Cancer Treatment Combination Takes Down Patient-derived Colorectal Cancer Initiating Cells

Researchers show how the inhibition of a DNA repair mediator may represent an exciting means to potentiate chemotherapy in colorectal cancer patients 

BRG1 Chromatin Remodeler: A New Target for the Treatment of Highly Aggressive and Malignant Brain Tumors?

Researchers chromatin remodeler expression in glioblastoma multiforme discover how BRG1 maintains cancer stem cell-identity and represents a therapeutic target

TAP1: The Key to Immune Evasion by Breast Cancer Stem Cells?

Researchers demonstrate that epigenetic silencing of TAP genes in breast cancer stem cells play a crucial role in immune evasion mechanisms

Accelerating Liver Cancer Research with Three Dimensional Tumoroids

A new three-dimensional in vitro model of liver tumorigenesis may provide an efficient means to study cancer development and create new and effective therapies.

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