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Cancer Stem Cells

CSC Targeting in Breast Cancer

A new review discusses the mechanism of trastuzumab resistance in cancer stem cells associated with HER2‐positive breast cancer

EYA1 Regulates GSC Maintenance and Proliferation

A new study reports that EYA1 can regulate the proliferation and migration of glioma stem cells through the regulation of MYC

PKC‐β Modulated Metabolism in CLL BMSCs

New research links stromal metabolism and PKCβ expression in BMSCs after contact with CLL cells

TGFβ signaling and Variation in AML

Autonomous TGFβ signaling may underly the heterogeneity and variability of LSCs associated with AML

ERβ Signaling Reduces GSC Stemness

ERβ signaling inhibits GBM progression and improves survival by targeting GSCs

Signaling Pathways Controlling TNBC CSCs

A review summarizes the signaling pathways that regulate the proliferation and survival of triple negative breast cancer stem cells

m6A-modified RNA in CSCs

A recent review article provides a snapshot of the current advances relating to the role of the N6‐methyladenosine RNA modification in cancer stem cells

CD44+ Cells Drive Drug‐resistance in Prostate Cancer

Researchers discover the resistance of CD44+ prostate cancer stem cells to combined docetaxel/fenofibrate treatment

Lung Cancer Development Driven by a High-Plasticity Cell State

The existence of a high-plasticity cell state supports high tumorigenic capacity and drug resistance of lung adenocarcinoma cells and associates with poor patient prognosis

Mitochondrial Proteases in AML

A new perspective discusses the effects of genetically and chemically dysregulating mitochondrial proteases in AML

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