Cancer Stem Cells

The tripartite‐motif (TRIM) family of proteins participate in a variety of cellular functions and biological processes, and recent data has revealed their significant role in the acquisition and maintenance of the stem cell phenotype.

A new study provides insight into the extracellular signals that modulate liver CSC self‐renewal and highlights the inhibitory roles of Tcf7l1 in cancer

A recent STEM CELLS review article from the laboratory of

A STEM CELLS study from the group of Yuanliang Wang and Cheng Qian (Chongqing

Recent research highlighting the critical role of the tumor microenvironment in triple‐negative breast cancer (TNBC) development prompted researchers from the lab of Antoine E. Karnoub (Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA) to investigate the interaction of mesenchymal stem cells with TNBC cells.

Characteristics of the tumor microenvironment can inhibit CHD7 expression in glioblastoma tumor-initiating cells and prompt a pro-angiogenic response

Researchers show how the inhibition of a DNA repair mediator may represent an exciting means to potentiate chemotherapy in colorectal cancer patients 

Researchers chromatin remodeler expression in glioblastoma multiforme discover how BRG1 maintains cancer stem cell-identity and represents a therapeutic target

Researchers demonstrate that epigenetic silencing of TAP genes in breast cancer stem cells play a crucial role in immune evasion mechanisms

A new three-dimensional in vitro model of liver tumorigenesis may provide an efficient means to study cancer development and create new and effective therapies.