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Haematopoetic Stem Cells

Loss of Myc mRNA Methylation Breaks the Symmetry of Hematopoietic Stem Cells

A new study establishes that the m6A modification helps to regulate the symmetric commitment of hematopoietic stem cells by controlling Myc mRNA stability

Purine Salvaging in Hematopoietic Stem Cells

Given that metabolism controls stem cell function and that purine metabolism represents a critical component of cellular metabolism, researchers from the laboratory of Hartmut Geiger

CD166-CD166 Interaction Enhances Hematopoietic Stem Cell Function

A new study suggests that CD166 interactions activate critical molecular pathways involved in enhancing hematopoietic stem/progenitor cell functions

CD166 Interactions and Hematopoietic Function

A previous study out of the labs of Hal E.

Transcription Factor Cooperation Drives Human Hematopoietic Stem and Progenitor Cell Specification

Researchers describe how transcription factor cooperation aids the generation of hemogenic precursors from human fibroblasts via an endothelial intermediate

The Human Intestine as a New Reservoir for Functional Hematopoietic Stem and Progenitor Cells

A report now establishes that intestinal graft-resident HSPCs contribute to long-term multilineage blood chimerism after human intestinal transplantation

Enhancing CRISPR/Cas9 Gene Editing of Human Hematopoietic Stem Cells

A Cas9 variant with cell cycle-specific activity coupled with cell synchronization improves the efficiency of hematopoietic stem cell gene editing

Hematopoietic Stem Cell Sorting: Keeping it Simple with a CD11a and EPCR Combination

A simple combination of two markers may provide a quick and easy means to sort mouse hematopoietic stem cell from blood samples

Enhancing the Clinical Potential of Umbilical Cord Blood on Hematopoietic Recovery

A study highlights an efficient means to expand hematopoietic stem/progenitor cells in non-enriched umbilical cord blood thereby boosting clinical potential

New HSC Rejuvenation Strategy May Improve Bone Marrow Transplantation

Researchers discover that treatment with microvesicles from young MSCs can rejuvenate aged HSCs and potentially improve bone marrow transplantation outcomes


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