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Haematopoetic Stem Cells

CXCL12 Protects from Radiation and Mobilizes HSPCs

In a recent STEM CELLS article, researchers led by

Induced Homing of Stem Cells Improves Hematopoietic Stem Cell Transplantation Outcomes

A single dose of thrombopoietin fosters significant improvements in hematopoietic stem/progenitor cell homing to the bone marrow and short‐ and long‐term engraftment in mice

HDAC Inhibitor Treatment Boosts Adult HSC Culture

HDAC inhibitor-mediated expansion of HSCs derived from the peripheral blood and bone marrow of healthy adult donors may aid the development of safe and effective therapies

CXCR4 Required for HSPC Maintenance

A recent STEM CELLS 

Genome Editing of Adult Stem Cells

In a new review article in STEM CELLS Translational Medicine, researchers led by

Novel Role for Thrombopoietin In HSPC Homing

A new study led by Hengxiang Wang (Medical Center of Air Forces), Yanhua Li (Beijing Institute of Radiation Medicine), and Xuetao Pei (Institute of Health Service and Transfusion Medicine, Beijing, China) describes a novel function of recombinant human thrombopoietin (TPO) in increasing hematopoietic stem and progenitor cell (HSPC) homing to the bone marrow, which subsequently results in enhan

Hes1 Loss leads to HSC Exhaustion

A recent STEM CELLS study from the lab of

Unleashing HSCT with Next Generation Approaches

Hematopoietic stem cell transplantation (HSCT) is commonly used to treat leukemias and severe disorders of the blood and immune system; however, the extension of HSCT to many patients in need of transplant, or into various new areas of disease that might benefit, remains problematic.

Exploring Advanced Culture Substrates to Enhance Stem Cell Transplants

A new culture strategy may allow for improved hematopoietic outcomes following cord blood transplants in patients undergoing myeloablative therapy

Ex Vivo Expansion of Adult HSCs With Valproic Acid

A new article from researchers led by Eran Zimran (Hadassah University Center, Jerusalem, Israel) recently described how the transplantation of


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