Haematopoetic Stem Cells

A clinical trial evaluates autologous BMMNC transplantation combined with educational intervention for children with autism spectrum disorder

A new review article discusses the clinical and molecular aspects of fusion genes associated with acute and chronic myeloid malignancies

An article provides insight into human T cell development, which may be useful for clinical translation to patients undergoing cord blood HSC transplantation

Patient‐specific hematopoietic stem cells derived from pluripotent stem cells offer a means to treat hematological diseases that currently suffer from a lack of viable therapeutic options. 

The observations of this study may suggest targets for therapeutic interventions in diseases associated with blood group receptors and in ABO mismatched transfusion and organ transplantation

Researchers establish the activation of both p38α and mammalian target of rapamycin complex 1 in ex vivo expanded human umbilical cord blood-derived HSCs

Bone marrow stromal cells express CXCR4 and bone marrow SDF‐1‐CXCR4 signaling regulates HSPC maintenance, self‐renewal, and hematopoietic reconstitution

Patients with refractory angina who are suboptimal candidates for further revascularization display improved exercise time, decreased angina frequency, and reduced major adverse cardiac events following the intramyocardial delivery of CD34+ stem cells; however, the effect of CD34+ stem cell therapy on health care expenditures after treatment remains unclear.

The manipulation of hematopoietic stem and progenitor cell homing represents a fascinating approach to the improvement of engraftment following hematopoietic stem cell transplantation. Additionally, the homing of mesenchymal stem cells to sites of injury and regeneration also represents an essential step in tissue repair.

A new STEM CELLS Translational Medicine article from the lab of Gian Paolo Fadini (