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Haematopoetic Stem Cells

AML Inhibits HSPC Function

Acute myeloid leukemia cell-secreted factors such as TGFβ1 inhibit essential functions of CD34+ hematopoietic stem and progenitor cells

CD34‐positive Cells for Human AKI

Researchers report the first‐in‐human phase I/II clinical trial of autologous mobilized peripheral blood CD34‐positive cell transplantation for severe acute kidney injury

Wnt4 Induces HSPC Self‐renewal

New findings suggest Wnt4 as a candidate to promote blood cell production by hematopoietic stem/progenitor cells after chemotherapy

Advanced Imaging Technique Describes the in vivo Anatomy of Myelopoiesis

New research highlights a crucial role for local cues from distinct blood vessels in the spatial organization of definitive myeloid differentiation

An Old Nice Restrains Rejuvenated HSCs

New findings imply that the sustainable rejuvenation of aged hematopoietic stem cells in vivo must address the influence of an aged niche

Meta‐analysis of Gene-edited Cell Persistence

A systematic review of CRISPR/Cas9-gene-edited hematopoietic stem cells highlights the need to develop new targeting strategies

O‐GlcNAcylation Regulates Megakaryopoiesis and Thrombopoiesis

A new study explores how O‐GlcNAcylation levels affects hematopoietic stem/progenitor cell differentiation

RAS and the Embryonic Emergence of HSPCs

Local active RAS exists in this hemogenic site and contributes to blood generation

Defining the Molecular Requirements for Human Lymphopoiesis

A review discusses how studies of primary immunodeficiencies can widen our understanding of lymphopoiesis

Regulating the Haematopoietic Niche with Nanoparticle-targeted Small Interfering RNAs

A nanoparticle carrying siRNAs targeting the endothelial cells of the hematopoietic niche can alter stem/progenitor cell behavior and systemic leukocyte supply


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