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Haematopoetic Stem Cells

Regulating the Haematopoietic Niche with Nanoparticle-targeted Small Interfering RNAs

A nanoparticle carrying siRNAs targeting the endothelial cells of the hematopoietic niche can alter stem/progenitor cell behavior and systemic leukocyte supply

Augmenting HSPC Regeneration with Sirolimus

Sirolimus administration might represent a clinically-relevant means to treat/prevent hematopoietic injury

Myeloid Progenitors Present in the Leptomeninges

Researchers report that the leptomeningeal barrier of the brain is continuously patrolled by bone marrow-derived progenitors

IRF7-CXCR4 Axis Suppresses Stress Hematopoiesis

IRF7 deficiency enhances regeneration of hematopoietic stem and progenitor cells (HSPCs) under conditions of stress

Deciphering the Role of Separase in HSCs and Hematopoiesis

Researchers have employed an engineered mouse model to fully explore the role of Separase in hematopoiesis and the function of hematopoietic stem cells

Insight into HSC Transplantation

A new review links researchers and clinicians by discussing the implications of recent HSC research in model organisms

Lower Oxygen Levels Provide a Boost For T-Cell Therapies

Hematopoietic stem cell culture in conditions that mimics the thymic niche enhances T lymphocyte progenitor cell production and maturation in thymic organoids

Cold Temperatures Provide a Boost for Cord Blood Stem Cell Transplantation

The processing of cord blood under lower-than-normal temperatures enhances the numbers of phenotypically and functionally defined self‐renewing HSCs

Separase Disruption Promotes HSC Regeneration

A new study reports a novel role for the cohesin protease, Separase, in hematopoiesis and hematopoietic stem cell function

Haplo-HSC And Allogenic MSC For Juvenile SAA

MSC and HSC cotransplantation yields high engraftment, rapid hematopoietic reconstitution, and a low incidence of acute and chronic GvHD

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