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Haematopoetic Stem Cells

Cold Temperatures Provide a Boost for Cord Blood Stem Cell Transplantation

The processing of cord blood under lower-than-normal temperatures enhances the numbers of phenotypically and functionally defined self‐renewing HSCs

Separase Disruption Promotes HSC Regeneration

A new study reports a novel role for the cohesin protease, Separase, in hematopoiesis and hematopoietic stem cell function

Haplo-HSC And Allogenic MSC For Juvenile SAA

MSC and HSC cotransplantation yields high engraftment, rapid hematopoietic reconstitution, and a low incidence of acute and chronic GvHD

Stem Cell Therapy in Refractory Angina Increases Survival and Reduces Costs for Patients

CD34-positive stem cell therapy improves mortality and reduces both hospital visits and expenditures for cardiac procedures in the year following treatment

BMMNC and Interventional Education for ASD

A clinical trial evaluates autologous BMMNC transplantation combined with educational intervention for children with autism spectrum disorder

Fusion Genes in Myeloid Malignancies

A new review article discusses the clinical and molecular aspects of fusion genes associated with acute and chronic myeloid malignancies

Enhancing T cell development from HSPCs with Physioxia

An article provides insight into human T cell development, which may be useful for clinical translation to patients undergoing cord blood HSC transplantation

Clinical Potential, Challenges, and Perspectives of PSC-HSCs

Patient‐specific hematopoietic stem cells derived from pluripotent stem cells offer a means to treat hematological diseases that currently suffer from a lack of viable therapeutic options. 

MicroRNAs Regulate ABO Expression

The observations of this study may suggest targets for therapeutic interventions in diseases associated with blood group receptors and in ABO mismatched transfusion and organ transplantation

Maintenance of Stemness in ex vivo Expanded HSCs

Researchers establish the activation of both p38α and mammalian target of rapamycin complex 1 in ex vivo expanded human umbilical cord blood-derived HSCs

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