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Haematopoetic Stem Cells

Exploring Advanced Culture Substrates to Enhance Stem Cell Transplants

A new culture strategy may allow for improved hematopoietic outcomes following cord blood transplants in patients undergoing myeloablative therapy

Ex Vivo Expansion of Adult HSCs With Valproic Acid

A new article from researchers led by Eran Zimran (Hadassah University Center, Jerusalem, Israel) recently described how the transplantation of

Loss of Myc mRNA Methylation Breaks the Symmetry of Hematopoietic Stem Cells

A new study establishes that the m6A modification helps to regulate the symmetric commitment of hematopoietic stem cells by controlling Myc mRNA stability

Purine Salvaging in Hematopoietic Stem Cells

Given that metabolism controls stem cell function and that purine metabolism represents a critical component of cellular metabolism, researchers from the laboratory of Hartmut Geiger

CD166-CD166 Interaction Enhances Hematopoietic Stem Cell Function

A new study suggests that CD166 interactions activate critical molecular pathways involved in enhancing hematopoietic stem/progenitor cell functions

CD166 Interactions and Hematopoietic Function

A previous study out of the labs of Hal E.

Transcription Factor Cooperation Drives Human Hematopoietic Stem and Progenitor Cell Specification

Researchers describe how transcription factor cooperation aids the generation of hemogenic precursors from human fibroblasts via an endothelial intermediate

The Human Intestine as a New Reservoir for Functional Hematopoietic Stem and Progenitor Cells

A report now establishes that intestinal graft-resident HSPCs contribute to long-term multilineage blood chimerism after human intestinal transplantation

Enhancing CRISPR/Cas9 Gene Editing of Human Hematopoietic Stem Cells

A Cas9 variant with cell cycle-specific activity coupled with cell synchronization improves the efficiency of hematopoietic stem cell gene editing

Hematopoietic Stem Cell Sorting: Keeping it Simple with a CD11a and EPCR Combination

A simple combination of two markers may provide a quick and easy means to sort mouse hematopoietic stem cell from blood samples

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