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Haematopoetic Stem Cells

MicroRNAs Regulate ABO Expression

The observations of this study may suggest targets for therapeutic interventions in diseases associated with blood group receptors and in ABO mismatched transfusion and organ transplantation

Maintenance of Stemness in ex vivo Expanded HSCs

Researchers establish the activation of both p38α and mammalian target of rapamycin complex 1 in ex vivo expanded human umbilical cord blood-derived HSCs

Deciphering the Role of Bone Marrow Niche Signals to Hematopoietic Stem Cell Activity

Bone marrow stromal cells express CXCR4 and bone marrow SDF‐1‐CXCR4 signaling regulates HSPC maintenance, self‐renewal, and hematopoietic reconstitution

CD34+ Stem Cell Therapy for Refractory Angina`

Patients with refractory angina who are suboptimal candidates for further revascularization display improved exercise time, decreased angina frequency, and reduced major adverse cardiac events following the intramyocardial delivery of CD34+ stem cells; however, the effect of CD34+ stem cell therapy on health care expenditures after treatment remains unclear.

Reviewing the Therapeutic Importance of Stem Cell Homing

The manipulation of hematopoietic stem and progenitor cell homing represents a fascinating approach to the improvement of engraftment following hematopoietic stem cell transplantation. Additionally, the homing of mesenchymal stem cells to sites of injury and regeneration also represents an essential step in tissue repair.

Plerixafor in Diabetic Wound Healing

A new STEM CELLS Translational Medicine article from the lab of Gian Paolo Fadini (

CXCL12 Protects from Radiation and Mobilizes HSPCs

In a recent STEM CELLS article, researchers led by

Induced Homing of Stem Cells Improves Hematopoietic Stem Cell Transplantation Outcomes

A single dose of thrombopoietin fosters significant improvements in hematopoietic stem/progenitor cell homing to the bone marrow and short‐ and long‐term engraftment in mice

HDAC Inhibitor Treatment Boosts Adult HSC Culture

HDAC inhibitor-mediated expansion of HSCs derived from the peripheral blood and bone marrow of healthy adult donors may aid the development of safe and effective therapies

CXCR4 Required for HSPC Maintenance

A recent STEM CELLS 

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