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Haematopoetic Stem Cells

Niche Comparisons Identify PGI2 as a New Means to Support and Protect HSCs

A transcriptional comparison of hematopoietic stem cell niches identifies PGI2 as an endosteal bone marrow-associated factor that functions at cell-intrinsic and cell-extrinsic levels

Epigenetic Priming in HSCs and Macrophages Promotes Diabetes-associated Cardiovascular Complications

High glucose levels epigenetically prime HSCs and macrophages to support the persistence of diabetes-related macrovascular complications

Autologous Cell-based Treatment for Severe Acute Kidney Injury in a Human Patient

A new study describes the first case of G-CSF-mobilized autologous CD34-positive cell transplantation as a treatment for acute kidney injury

Stem Cell Secretome Guides Therapeutic Outcomes in the Infarcted Heart

The cardiopoietic stem cell secretome confers a therapeutic molecular imprint on recipient hearts, while predictive systems profiling could inform on therapeutic responses

Somatic Mutations Help to Map out Human Development

A new study uses somatic mutations and single-cell analysis to describe the unknowns of human development

How the Aged Stem Cell Niche Impacts Rejuvenated HSCs

A new study suggests that the rejuvenation of the hematopoietic system must take hematopoietic stem cells and the stem cell niche into account

Prostacyclin Protects Stressed-out HSCs

Researchers report their discovery of prostacyclin as a novel hematopoietic stem cell regulator enriched in endosteal bone marrow niches

HSCs as an Osteogenesis Imperfecta Treatment

Researchers establish hematopoietic stem cell transplantation as a potentially exciting therapy bone repair in osteogenesis imperfecta

Glucose Oxidase Mobilizes HSPCs

Glucose oxidase promotes peripheral mobilization of hematopoietic stem/progenitor cells that maintain their function in conditioned recipients

Chaperone-mediated Autophagy Takes the Stress off HSCs

Targeting chaperone-mediated autophagy may represent an exciting means to enhance HSC function during the normal aging process or after stem cell transplantation


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