Muscle Stem Cells

O‐GlcNAcylation plays a critical role in maintaining satellite cell health and function in both normal and injured skeletal muscle

O‐GlcNAcylation in satellite cells helps to maintain homeostasis and adjust behavior under normal conditions and during adult regenerative myogenesis

A new study suggests 15-hydroxyprostaglandin dehydrogenase inhibition as a means to counteract the loss of muscle function observe during normal aging

While transplanted human iPSC-derived skeletal muscle cells become infiltrated by immune cells after transplantation, this does not negatively impact engraftment

A novel treatment targets the muscle stem cell niche to promote myogenesis, angiogenesis, and neovascularization

Stem cells within denervated muscle maintain regenerative capabilities comparable to those in uninjured muscle

C/EBPβ overexpression induces the expression of quiescence‐associated genes in myoblasts

The CalcR‐PKA‐Yap1 axis inhibits Dlk1 expression and Dlk1 loss rescues the impaired quiescent state in CalcR‐mutant MuSCs

Aging negatively impacts muscle regeneration through altered metabolism, chromatin, transcription factor binding, and gene expression in muscle stem cells

New research explores the modulation of the immune system following the transplantation of muscle stem cells into a mouse model of inflammatory bowel disease