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Muscle Stem Cells

Exploring the Immunogenicity of Human iPSC-derived Cells

While transplanted human iPSC-derived skeletal muscle cells become infiltrated by immune cells after transplantation, this does not negatively impact engraftment

Skeletal Muscle Regeneration by Hippo Inhibition

A novel treatment targets the muscle stem cell niche to promote myogenesis, angiogenesis, and neovascularization

MuSC Activation and Regenerative Potential After Denervation

Stem cells within denervated muscle maintain regenerative capabilities comparable to those in uninjured muscle

CEBPβ Promotes MuSC Quiescence

C/EBPβ overexpression induces the expression of quiescence‐associated genes in myoblasts

Dlk1 Regulates CalcR‐mutant MuSC Quiescence

The CalcR‐PKA‐Yap1 axis inhibits Dlk1 expression and Dlk1 loss rescues the impaired quiescent state in CalcR‐mutant MuSCs

Alterations to Silent Chromatin Underlie Loss of Function in Aging Stem Cells

Aging negatively impacts muscle regeneration through altered metabolism, chromatin, transcription factor binding, and gene expression in muscle stem cells

Muscle Stem Cells – New Players in the Treatment of Inflammatory Diseases?

New research explores the modulation of the immune system following the transplantation of muscle stem cells into a mouse model of inflammatory bowel disease

Muscle Stem Cells Produce IGF-2

Inflammatory macrophages can promote the expansion of activated muscle stem cells during tissue repair by retaining cells in a proliferative and undifferentiated state.

Transcriptional Identities of Fetal Mesoangioblasts

A new study published in STEM CELLS Translational Medicine

Dystrophin Restoration in Muscle Progenitor Cells

The lack of dystrophin in muscle myofibers represents the central cause of Duchenne muscular dystrophy (DMD), the most common inherited muscular dystrophy; however, evidence suggests that DMD may also be a stem cell disease.

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