While transplanted human iPSC-derived skeletal muscle cells become infiltrated by immune cells after transplantation, this does not negatively impact engraftment
New research explores the modulation of the immune system following the transplantation of muscle stem cells into a mouse model of inflammatory bowel disease
Inflammatory macrophages can promote the expansion of activated muscle stem cells during tissue repair by retaining cells in a proliferative and undifferentiated state.
The lack of dystrophin in muscle myofibers represents the central cause of Duchenne muscular dystrophy (DMD), the most common inherited muscular dystrophy; however, evidence suggests that DMD may also be a stem cell disease.