Muscle Stem Cells

While transplanted human iPSC-derived skeletal muscle cells become infiltrated by immune cells after transplantation, this does not negatively impact engraftment

A novel treatment targets the muscle stem cell niche to promote myogenesis, angiogenesis, and neovascularization

Stem cells within denervated muscle maintain regenerative capabilities comparable to those in uninjured muscle

C/EBPβ overexpression induces the expression of quiescence‐associated genes in myoblasts

The CalcR‐PKA‐Yap1 axis inhibits Dlk1 expression and Dlk1 loss rescues the impaired quiescent state in CalcR‐mutant MuSCs

Aging negatively impacts muscle regeneration through altered metabolism, chromatin, transcription factor binding, and gene expression in muscle stem cells

New research explores the modulation of the immune system following the transplantation of muscle stem cells into a mouse model of inflammatory bowel disease

Inflammatory macrophages can promote the expansion of activated muscle stem cells during tissue repair by retaining cells in a proliferative and undifferentiated state.

A new study published in STEM CELLS Translational Medicine

The lack of dystrophin in muscle myofibers represents the central cause of Duchenne muscular dystrophy (DMD), the most common inherited muscular dystrophy; however, evidence suggests that DMD may also be a stem cell disease.