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Mesenchymal Stem Cells

MSC-induced Immunosuppression in Asthma

In a new STEM CELLS Translational Medicine article, researchers from the laboratory

Are All Stem Cells Equal in BPD?

A research team led by Sajit Augustine (Western University, Ontario, Canada) recently performed a systematic review and network me

Single-cell Profiling of Bone Forming Progenitor Cells

While attaining a critical number of in vitro expanded progenitor cells provides the key driving force in a cell‐based regenerative construct, the standard expansion protocols currently employed affect the initial cellular phenotype due to a focus on rapid expansion and not maintenance of progenitor potential.

Intracarotid Artery Transplantation of MSCs for Ischemic Stroke

A new study from the lab of Cesar V. Borlongan (University of South Florida, Tampa, Florida, USA) studied mesenchymal stem cells (MSCs) as a means to treat ischemic stroke with the recognition that critical translational gaps in stem cell transplant dose, route, and timing after stroke exist while acknowledging the need for a solid safety profiles for MSCs.

KLF2 Enhances Bone Regeneration by MSCs and ECs

A team of researchers led by Mengfei Yu and Huiming Wang (Zhejiang University, Hangzhou, China) recently investigated KLF2 as a novel in vitro marker for mesenchymal stem cells (MSCs) to investigate osteogenesis and angiogenesis following the interaction between KLF2+ MSCs and endothelial cells (ECs). Zhou et al.

MSC Sheets Suppress Renal Fibrosis

Renal fibrosis treatment strategies have previously employed the intravascular administration of stem cells.

Cell-Based Therapies for Periodontal Regeneration

Cell‐based therapies have the potential to improve outcomes of orally-associated regenerative treatments; as an example, mesenchymal stem cells currently represent ideal candidates for adjuvant application for extraction sockets and challenging lateral/vertical bone defects requiring bone block grafts.

Antibacterial Activity of Human MSCs

A new study led by researchers from the lab of Steven Dow (Colorado State University, Fort Collins, Colorado, USA) recently reported the antimicr

MFAT vs. BMAC: Mesenchymal Stem Cell Therapy Showdown for Osteoarthritis Treatment

A study compares the ability of intra‐articular injections of MSCs to provide pain and functional improvements in symptomatic knee osteoarthritis patients

Tunable Hydrogels for Mesenchymal Stem Cell Delivery

Stem cell therapies hold considerable promise, but their clinical application requires the development of appropriate delivery platforms; this includes synthetic hydrogels engineered to display fibrin‐like and other cell‐binding sites that promote cell adhesion and direct stem cell function and fate through “outside-in” signaling mechanisms.

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