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Mesenchymal Stem Cells

Role of SLIT3-ROBO1 in MSCs

While many mesenchymal stem cell (MSC) therapies find themselves under advanced clinical evaluation, the tissue‐specific pro‐regenerative properties of MSCs remain poorly understood.

COVID-19 and Cell-based Therapy

Severe cases of COVID‐19 infection have been associated with variants of acute respiratory distress syndrome (ARDS). Mesenchymal stem cell (MSC) therapy modulates inflammatory and remodeling processes and restores alveolo‐capillary barriers, and therefore represents a promising treatment approach for ARDS.

Mechanosensitive Mechanisms Regulate Human MSCs

Mesenchymal stem cells (MSCs) secrete Stanniocalcin‐1 (STC1), a relatively undescribed glycoprotein that possesses anti‐inflammatory abilities, reduces apoptosis, and promotes angiogenesis both in vitro and in vivo. The control of these cellular responses represents an important aspect of regenerative medicine and tissue engineering; however, we still lack a full understanding of STC1 regulation.

Enhanced Therapeutic Effects with CD146-positive MSCs

A study led by Diego Correa (University of Miami, Florida, USA) recently described a CD146-positive subpopulation of mesenchymal stem cell

Wnt7b-Sox11 Axis Mediates BM-MSC Bone Regeneration

In a new STEM CELLS study led by Ling Ye (Sichuan University, People's Republic of Chin

MSCs Induce Tregs via Epigenetic Conversion of Tcons

Regulatory T cells (Treg) have been increasingly recognized for their application in the treatment of chronic inflammatory diseases; however, their scarcity requires in vitro expansion to obtain clinically relevant cell numbers. While mesenchymal stem cells (MSCs) have been suggested to recruit Treg in vitro, we still lack a full understanding of the underlying mechanisms.

N‐glycosylation Mediates Immunosuppression by MSCs

Mesenchymal stem cells (MSCs) possess immunoregulatory properties and are hypoimmunogenic, making them promising candidates for cell therapy approaches in hyperinflammatory conditions such as graft‐vs‐host disease as a consequence of allogeneic stem cell transplantation.

Secretome in Ligament or Tendon Healing

Many therapeutic approaches have been evaluated for the treatment of tendon or ligament tear injuries, which can significantly affect the patient’s quality of life. While studies have provided evidence for mesenchymal stem cells (MSCs) as an effective therapeutic strategy for the treatment of tendon or ligament tears, we currently lack a full assessment of the role of the MSC secretome.

GARP Overexpression During In Vitro Expansion May Provide a Boost for MSC-based Therapies

A new study suggests that GARP-mediated regulation of TGF‐β activation/signaling can allow mesenchymal stem cells to safely proliferate under stress-inducing conditions

How Umbilical Cord MSCs Ameliorate Atopic Dermatitis

The mechanism underlying the therapeutic effects of mesenchymal stem cells (MSCs) in atopic dermatitis remains unclear.

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