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Mesenchymal Stem Cells

GSTT1 – The Key to The Widespread Therapeutic Application of Human Mesenchymal Stem Cells?

Researchers identify the loss of glutathione S‐transferase theta 1 gene as a novel genomic DNA biomarker for human mesenchymal stem cell scalability

Mesenchymal Stem Cells, SARS-CoV-2, and Sepsis

Mesenchymal stem cell administration has been evaluated in preclinical models of ARDS, sepsis, and septic shock, and in clinical trials

Corroborating that Less is More for MSCs

Further support for GSTT1 loss as a useful genomic DNA biomarker to prospectively screen human donors before MSC collection

Mesenchymal Cells and Angiogenesis

A new review article provides an overview of the current knowledge on the therapeutic potential of MSCs and MSC‐derived extracellular vesicles

BMP2 Gene-activated Scaffold for Bone Formation

 A novel gene‐engineered, cell‐based bone construct represents a robust treatment method for cranial defects

CD146-sorted Mesenchymal Stem Cells Provide for Enhanced Therapeutic Outcomes

Homogenous populations of perivascular-like MSCs might exhibit more robust responses to inflammatory insult and provide a more “powerful” therapeutic approach

Mechanically Activated EV-based Osteogenesis

Osteocyte‐derived mechanically-activated extracellular vesicles hold great potential as a novel cell‐free therapy to enhance bone regeneration

Functional Markers for MSC Therapy in Osteoarthritis

MSC chondrogenesis represents a transient property lost as cells age in vitro, whereas trophic repair potency is maintained until MSCs cease to grow. 

Alternative Splicing in MSC Differentiation

A new review article in STEM CELLS discusses the underrated role of alternative splicing, a process that produces multiple similar but functionally distinct proteins from one gene, in MSC differentiation

MSC Therapy for cGvHD

Mesenchymal stem cell (MSC) therapy represents a promising option for the treatment of steroid‐refractory chronic graft‐vs‐host disease (cGvHD); however, we lack clinical trial data, and the mechanisms of action remain unknown.

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