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Mesenchymal Stem Cells

Metabolic Syndrome Promotes a Pro-inflammatory Profile in MSC-derived Extracellular Vesicles

Metabolic syndrome may impair the therapeutic ability of mesenchymal stem cell-derived extracellular vesicles by promoting a proinflammatory EV profile

Improving Tendon Healing with Proregenerative Educated Macrophages

Macrophages educated to a proregenerative M2‐like state after exposure to MSC-derived extracellular vesicles promote regeneration in a mouse tendon rupture model

Mesenchymal Stem Cell Study Takes a Step Towards the Cell-free Treatment of Diabetes

Research identifies hBM-MSC derived factors that promote islet regenerative and may permit the development of cell‐free therapies for diabetic patients

Potentiating the Therapeutic Activity of Mesenchymal Stem Cells for Asthma Treatment

Researchers report that pretreating MSCs with serum from asthmatic mice leads to a reduction in lung inflammation and remodeling and improves lung function 

Mesenchymal Stem Cells and Stimulated Macrophages: An Efficient Combination Treatment for Cirrhosis?

Researchers discover enhanced liver repair following treatment with mesenchymal stem cells and stimulated macrophages in a mouse model of cirrhosis

Single-cell Analysis Reveals the Impact of Aging on Mesenchymal Stem Cells

New research reports that young MSCs promote more rapid wound healing than old MSCs and uncovers single-cell age-related transcriptional differences

Novel Long non-coding RNA Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells

Researchers discover a novel lncRNA linked to the osteogenesis of bone marrow MSCs and also describe the crucial interaction of this lncRNA with hnRNPK

Epigenetic Control of Bone Formation by Ash1l: A New Target for the Treatment of Bone Disorders?

Researchers describe how targeting the activity of a histone methyltransferase may lead to the development of improved therapies for common bone disorders

Metabolic Switch Supports Human Mesenchymal Stem Cell Immunosuppression

Researchers describe the metabolic alterations in MSCs following immune licensing that support the secretion of  key immunosuppressive factors

Serum-free Growth Media Improves Mesenchymal Stem Cell Therapy for Chronic Kidney Disease

Researchers searching for a therapy for kidney damage establish the advantages of cultivating mesenchymal stem cells in serum-free media prior to application

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