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Mesenchymal Stem Cells

NCAM Regulates Chondrocyte Hypertrophy

Osteoarthritis (OA) patients suffer from irreversible and challenging to repair defects in the cartilage; however, mesenchymal stem cell (MSC)-based cartilage regeneration may represent an exciting approach if we can inhibit the excessive chondrocyte hypertrophy observed in the inflammatory intra‐articular conditions of OA.

MSC-induced Immunosuppression in Asthma

In a new STEM CELLS Translational Medicine article, researchers from the laboratory

Are All Stem Cells Equal in BPD?

A research team led by Sajit Augustine (Western University, Ontario, Canada) recently performed a systematic review and network me

Single-cell Profiling of Bone Forming Progenitor Cells

While attaining a critical number of in vitro expanded progenitor cells provides the key driving force in a cell‐based regenerative construct, the standard expansion protocols currently employed affect the initial cellular phenotype due to a focus on rapid expansion and not maintenance of progenitor potential.

Intracarotid Artery Transplantation of MSCs for Ischemic Stroke

A new study from the lab of Cesar V. Borlongan (University of South Florida, Tampa, Florida, USA) studied mesenchymal stem cells (MSCs) as a means to treat ischemic stroke with the recognition that critical translational gaps in stem cell transplant dose, route, and timing after stroke exist while acknowledging the need for a solid safety profiles for MSCs.

KLF2 Enhances Bone Regeneration by MSCs and ECs

A team of researchers led by Mengfei Yu and Huiming Wang (Zhejiang University, Hangzhou, China) recently investigated KLF2 as a novel in vitro marker for mesenchymal stem cells (MSCs) to investigate osteogenesis and angiogenesis following the interaction between KLF2+ MSCs and endothelial cells (ECs). Zhou et al.

MSC Sheets Suppress Renal Fibrosis

Renal fibrosis treatment strategies have previously employed the intravascular administration of stem cells.

Cell-Based Therapies for Periodontal Regeneration

Cell‐based therapies have the potential to improve outcomes of orally-associated regenerative treatments; as an example, mesenchymal stem cells currently represent ideal candidates for adjuvant application for extraction sockets and challenging lateral/vertical bone defects requiring bone block grafts.

Antibacterial Activity of Human MSCs

A new study led by researchers from the lab of Steven Dow (Colorado State University, Fort Collins, Colorado, USA) recently reported the antimicr

MFAT vs. BMAC: Mesenchymal Stem Cell Therapy Showdown for Osteoarthritis Treatment

A study compares the ability of intra‐articular injections of MSCs to provide pain and functional improvements in symptomatic knee osteoarthritis patients

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