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Mesenchymal Stem Cells

Mechanosensitive Mechanisms Regulate Human MSCs

Mesenchymal stem cells (MSCs) secrete Stanniocalcin‐1 (STC1), a relatively undescribed glycoprotein that possesses anti‐inflammatory abilities, reduces apoptosis, and promotes angiogenesis both in vitro and in vivo. The control of these cellular responses represents an important aspect of regenerative medicine and tissue engineering; however, we still lack a full understanding of STC1 regulation.

Enhanced Therapeutic Effects with CD146-positive MSCs

A study led by Diego Correa (University of Miami, Florida, USA) recently described a CD146-positive subpopulation of mesenchymal stem cell

Wnt7b-Sox11 Axis Mediates BM-MSC Bone Regeneration

In a new STEM CELLS study led by Ling Ye (Sichuan University, People's Republic of Chin

MSCs Induce Tregs via Epigenetic Conversion of Tcons

Regulatory T cells (Treg) have been increasingly recognized for their application in the treatment of chronic inflammatory diseases; however, their scarcity requires in vitro expansion to obtain clinically relevant cell numbers. While mesenchymal stem cells (MSCs) have been suggested to recruit Treg in vitro, we still lack a full understanding of the underlying mechanisms.

N‐glycosylation Mediates Immunosuppression by MSCs

Mesenchymal stem cells (MSCs) possess immunoregulatory properties and are hypoimmunogenic, making them promising candidates for cell therapy approaches in hyperinflammatory conditions such as graft‐vs‐host disease as a consequence of allogeneic stem cell transplantation.

Secretome in Ligament or Tendon Healing

Many therapeutic approaches have been evaluated for the treatment of tendon or ligament tear injuries, which can significantly affect the patient’s quality of life. While studies have provided evidence for mesenchymal stem cells (MSCs) as an effective therapeutic strategy for the treatment of tendon or ligament tears, we currently lack a full assessment of the role of the MSC secretome.

GARP Overexpression During In Vitro Expansion May Provide a Boost for MSC-based Therapies

A new study suggests that GARP-mediated regulation of TGF‐β activation/signaling can allow mesenchymal stem cells to safely proliferate under stress-inducing conditions

How Umbilical Cord MSCs Ameliorate Atopic Dermatitis

The mechanism underlying the therapeutic effects of mesenchymal stem cells (MSCs) in atopic dermatitis remains unclear.

Case Report Suggests that MSC Pretreatment Supports Long‐term Kidney Transplant Tolerance

Researchers explore the immunomodulatory mechanisms of mesenchymal stem cells and their long‐term graft tolerance induction capacity with regards to kidney transplant

Local Transplantation of BM-MSCs Improves Cell Therapy for Osteogenesis Imperfecta

Locally transplanted BM-MSCs continually give rise to osteoblasts and promote improvements to bone morphology and mechanical properties in an osteogenesis imperfecta model

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