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Mesenchymal Stem Cells

Magnetic Guidance Improves MSC Therapy

Although the systemic administration of mesenchymal stem cells (MSCs) ameliorates lung inflammation and attenuates fibrosis in experimental silicosis, MSC therapy fails to reverse collagen deposition and granuloma formation.

Notch and BMP-mediated Osteoblastogenesis

Stimulation via the canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMP) can induce the osteoblastic differentiation of bone-marrow-derived human mesenchymal stem cells (hMSC); however, the question as to how these two pathways lead to the same phenotypic outcome remains unanswered.

MSC Priming and Wound Healing

Mesenchymal stem cells (MSCs) can accelerate wound healing; however, the failure of MSCs or MSC‐conditioned medium to function in all cases suggests room for significant improvement.

MSCs in Lung Inflammatory Diseases and COVID-19

Immunomodulation through human mesenchymal stem cell (MSC) therapy represents a clinically relevant treatment approach that allows for allogeneic use and broad application in immune/inflammatory diseases. These include severe pulmonary injury and inflammatory conditions such as acute respiratory distress syndrome (ARDS), which is associated with bacterial and viral infections.

GDF11 Protects MSCs via YME1L

Growth differentiation factor 11 (GDF11) induces the fusion of mitochondrial networks in hypoxic mesenchymal stem cells (MSCs) through the ALK4/5‐p‐Smad2/3 pathway. Additionally, increased levels of the mitochondria protease YME1L rebalances OPA1 processing and inhibits mitochondrial fragmentation in hypoxic MSCs.

The Antioxidant Paradigm of MSC Therapy

The role of mesenchymal stem cells (MSCs) in ameliorating oxidative and nitrosative injury has received considerable attention in recent years. The reduction‐oxidation environment regulates a range of physiological and pathophysiological mechanisms in cellular biology, and the ability of MSCs to regulate reduction/oxidation is of considerable interest.

AD Treatment via Intranasally Delivered MSC-EVs

In an attempt to discover a possible treatment for Alzheimer's disease (AD), researchers led by Silvia Coco (University of Milano‐Bicocca, Monza, Italy) have in

Role of SLIT3-ROBO1 in MSCs

While many mesenchymal stem cell (MSC) therapies find themselves under advanced clinical evaluation, the tissue‐specific pro‐regenerative properties of MSCs remain poorly understood.

COVID-19 and Cell-based Therapy

Severe cases of COVID‐19 infection have been associated with variants of acute respiratory distress syndrome (ARDS). Mesenchymal stem cell (MSC) therapy modulates inflammatory and remodeling processes and restores alveolo‐capillary barriers, and therefore represents a promising treatment approach for ARDS.

Mechanosensitive Mechanisms Regulate Human MSCs

Mesenchymal stem cells (MSCs) secrete Stanniocalcin‐1 (STC1), a relatively undescribed glycoprotein that possesses anti‐inflammatory abilities, reduces apoptosis, and promotes angiogenesis both in vitro and in vivo. The control of these cellular responses represents an important aspect of regenerative medicine and tissue engineering; however, we still lack a full understanding of STC1 regulation.

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