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Mesenchymal Stem Cells

MSC Therapy for Osteogenesis Imperfecta Treatment

A new STEM CELLS article from the lab of Ivo Kalajzic (UConn Health, Farmington, Connecticut, USA) recently presented a novel translational approach for the treatment of osteogenesis imperfecta (OI).

Identifying an Optimal Meniscus‐derived Stem Cell Population for Regenerative Approaches

Researchers define an optimal population of rat meniscus tendon tissue-derived mesenchymal stem cells for use in meniscus repair and osteoarthritis suppression

Reviewing Stem Cell Therapies for OA

Despite the promise of stem cell‐based therapies as a treatment option for osteoarthritis (OA), results have fallen short of expectations.

MSC Trends and Dosing in Clinical Trials

A new study from the lab of Martin Grumet (Rutgers University, Piscataway, NJ, USA) assessed clinical

Novel Approach Enhances Mesenchymal Stem Cell-mediated Bone Repair

Anti-Smurf1 GapmeRs combine with biocompatible scaffolds that sustainably release BMP-2 as a safe, effective, and clinically translatable means to treat critical size bone fractures

LPAR4 regulates differentiation of MPCs

Osteoblasts and adipocytes originate from a common mesenchymal progenitor cell (MPC), and a competitive relationship exists between osteogenic and adipogenic differentiation.

SSCS Suppress Inflammatory Osteoclastogenesis

Recent basic and translational research has highlighted the promise of tissue‐specific stem cells from the skeleton or skeletal stem cells (SSCs). While they have been shown to contribute to skeletal development and regeneration, we still lack a full understanding of how these cells react during inflammatory bone disease.

Predicting BM-MSC Functions Using Imaging

Clinical trials employing cultured human bone marrow mesenchymal stem cells (hBM‐MSCs) have demonstrated the presence of significant inter‐donor variability in biological functions and clinical efficacy.

Intranasal Delivery of MSCs for BPD

Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in extremely premature neonates, and, unfortunately, current therapies for BPD are limited.

Piezo1 Channel Activation Drives MSC Migration

While mesenchymal stem cells (MSC) release ATP as an extracellular signaling molecule in response to mechanical and diverse other stimuli, the underlying mechanisms remain largely unknown.

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