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Mesenchymal Stem Cells

Towards an Optimized MSC-based Treatment of Ischemic Stroke

Appraisal of a well-characterized stem cell line in stroke models prompts a trial of intracarotid artery mesenchymal stem cell transplantation in ischemic stroke patients

Advanced Tunable MSC Delivery Strategy Promises to Boost Regenerative Approaches

A new study reports on the effects of tunable hydrogels on the regenerative capacity of MSCs, and how we may exploit this relationship to improve wound healing

Linking Nucleoskeletal Disruption to MSC Differentiation with mDia2

mDia2 retains mesenchymal stem cells in a multipotent state and represents an exciting tool that can be employed to query nuclear actin‐lamin nucleoskeletal structure

How MSCs Affect Regulatory T-reg Cells – A Review

Mesenchymal stem cells (MSCs) and regulatory T cells (T‐regs) are very different cell types; however, these cell types share the common features of actively suppressing or modulating harmful immune responses through diverse molecular mechanisms and of being the focus of extensive translational efforts as cell therapies for immune‐mediated/inflammatory diseases.

Exosomal CNP Promotes Recovery of Damaged Brain

Mesenchymal stem cells (MSCs) have vast therapeutic potential for the treatment for neurological diseases and damage, with many of their effects mediated by components of the stem cell secretome.

Mitochondrial Transfer from MSCs to Islet β-cells

Mesenchymal stem cells (MSCs) have direct effects on islet β‐cells that improve their insulin secretory function, and studies have highlighted the essential nature of the generation of ATP and other metabolic coupling factors by mitochondrial metabolism for nutrient‐induced insulin secretion.

Stem Cell Therapies Affect Clotting following Trauma

While various stem cell-based therapeutics are currently under investigation as a treatment option following trauma, such as brain or lung injury, stem cells readily express tissue factor (TF), which causes rapid blood clotting.

MSC-polarized Macrophages Alleviate Diabetic Nephropathy

While mesenchymal stem cells (MSCs) have been reported to prevent renal injuries via immune regulation in diabetic models, the mechanisms at play remain to be fully elucidated.

Phase III Trial of Autologous MSCs for Perianal Fistula

MSC-Induced Kidney Transplant Tolerance

A case report published in STEM CELLS Translational Medicine 

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