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Mesenchymal Stem Cells

Intracarotid Artery Transplantation of MSCs for Ischemic Stroke

A new study from the lab of Cesar V. Borlongan (University of South Florida, Tampa, Florida, USA) studied mesenchymal stem cells (MSCs) as a means to treat ischemic stroke with the recognition that critical translational gaps in stem cell transplant dose, route, and timing after stroke exist while acknowledging the need for a solid safety profiles for MSCs.

KLF2 Enhances Bone Regeneration by MSCs and ECs

A team of researchers led by Mengfei Yu and Huiming Wang (Zhejiang University, Hangzhou, China) recently investigated KLF2 as a novel in vitro marker for mesenchymal stem cells (MSCs) to investigate osteogenesis and angiogenesis following the interaction between KLF2+ MSCs and endothelial cells (ECs). Zhou et al.

MSC Sheets Suppress Renal Fibrosis

Renal fibrosis treatment strategies have previously employed the intravascular administration of stem cells.

Cell-Based Therapies for Periodontal Regeneration

Cell‐based therapies have the potential to improve outcomes of orally-associated regenerative treatments; as an example, mesenchymal stem cells currently represent ideal candidates for adjuvant application for extraction sockets and challenging lateral/vertical bone defects requiring bone block grafts.

Antibacterial Activity of Human MSCs

A new study led by researchers from the lab of Steven Dow (Colorado State University, Fort Collins, Colorado, USA) recently reported the antimicr

MFAT vs. BMAC: Mesenchymal Stem Cell Therapy Showdown for Osteoarthritis Treatment

A study compares the ability of intra‐articular injections of MSCs to provide pain and functional improvements in symptomatic knee osteoarthritis patients

Tunable Hydrogels for Mesenchymal Stem Cell Delivery

Stem cell therapies hold considerable promise, but their clinical application requires the development of appropriate delivery platforms; this includes synthetic hydrogels engineered to display fibrin‐like and other cell‐binding sites that promote cell adhesion and direct stem cell function and fate through “outside-in” signaling mechanisms.

MSC Mechanisms Improve ASO Distribution in HD

Antisense oligonucleotides (ASOs) represent promising therapeutic strategies for the suppression of toxic protein production in neurogenetic diseases, especially in Huntington's disease (HD); however, the pattern and mechanism of distribution of ASOs in the brain remain unclear.

Nucleoskeletal Regulation of MSC Differentiation

Nuclear morphology contributes to chromatin organization and gene expression, and now, researchers from the laboratory of Janet Rubin (University of No

MSC-EVS in ARDS - A Concise Review

A new STEM CELLS Translational Medicine review article discusses preclinical studie

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