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Mesenchymal Stem Cells

Mesenchymal Cells and Angiogenesis

A new review article provides an overview of the current knowledge on the therapeutic potential of MSCs and MSC‐derived extracellular vesicles

BMP2 Gene-activated Scaffold for Bone Formation

 A novel gene‐engineered, cell‐based bone construct represents a robust treatment method for cranial defects

CD146-sorted Mesenchymal Stem Cells Provide for Enhanced Therapeutic Outcomes

Homogenous populations of perivascular-like MSCs might exhibit more robust responses to inflammatory insult and provide a more “powerful” therapeutic approach

Mechanically Activated EV-based Osteogenesis

Osteocyte‐derived mechanically-activated extracellular vesicles hold great potential as a novel cell‐free therapy to enhance bone regeneration

Functional Markers for MSC Therapy in Osteoarthritis

MSC chondrogenesis represents a transient property lost as cells age in vitro, whereas trophic repair potency is maintained until MSCs cease to grow. 

Alternative Splicing in MSC Differentiation

A new review article in STEM CELLS discusses the underrated role of alternative splicing, a process that produces multiple similar but functionally distinct proteins from one gene, in MSC differentiation

MSC Therapy for cGvHD

Mesenchymal stem cell (MSC) therapy represents a promising option for the treatment of steroid‐refractory chronic graft‐vs‐host disease (cGvHD); however, we lack clinical trial data, and the mechanisms of action remain unknown.

Mesenchymal Stem Cells as Neural Therapeutics

A concise review article published recently in STEM CELLS Translational Medicine from Marcin Majka and Bogna Badyra (Jagiellonian University Medical College, Cracow, Poland)

MSC Secreted Factors – The New Player in the Battle Against Antibiotic-Resistant Bacteria

New research shows how MSC-secreted factors can impair biofilm formation by cutaneous wound‐related bacteria and disrupt mature biofilms via a protease‐dependent mechanism

Reviewing Glioblastoma-Mesenchymal Stem Cell Interactions

The unique properties of mesenchymal stem cells (MSCs) have made them an exciting resource for the treatment of a range of human conditions, including degenerative and inflammatory diseases, tissue damage, and cancer.

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