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Mesenchymal Stem Cells

TAK1 is a Critical Regulator of BM-MSC Proliferation

While bone marrow‐derived mesenchymal stem cells (BM-MSCs) represent a highly utile cell type for cell transplantation therapy, the molecular network underlying BM-MSC proliferation remains poorly understood. Now, researchers led by Takeshi Teramura (Kindai University, Osaka, Japan) report TGFβ‐activated kinase (Tak1) as a critical regulator of BM-MSC proliferation.

Understanding Metabolism to Improve MSC Survival

To develop the next generation of cell‐delivery materials and methods, we must have a better understanding of the metabolic switches mesenchymal stem cells (MSCs) experience upon transplantation. By designing treatment strategies with cell metabolism in mind, we may improve survival and the overall therapeutic potential of MSCs.

MSC-Derived Extracellular Vesicle Therapy

A new review article from the laboratory of David S.

Bmi1 Overexpression in MSCs - A Novel Means to Treat Aging-related Disease?

Research showing that Bmi1 overexpression exerts anti‐aging effects may permit the development of enhanced mesenchymal stem cell-based therapeutic approaches

Assessing iPSC-derived MSCs as a Therapeutic Approach to Obesity‐Associated Kidney Injury

Researchers hope that comparing mesenchymal stem cells from various sources will drive the development of an treatment for obesity‐related kidney injury

New Autologous MSC Trial in Osteoarthritic Patients Suggests Safety and Hints at Efficacy

A new clinical trial assesses autologous bone marrow-derived mesenchymal stem cell therapy in twelve patients with moderate to severe knee osteoarthritis

 

Preclinical MSC-Exosomes: A Review

The growing interest surrounding the therapeutic application of purified and concentrated regenerative factors secreted by mesenchymal stem cell (MSCs) has recently focused on exosomes, which are now understood to be critical active pharmaceutical ingredients of MSC‐based therapies.

Micronized Fat Versus BMAC for Knee Osteoarthritis

A recent STEM CELLS Translational Medicine article from the lab of Robert Bowers (Emory University, Atlanta, Georgia, USA) ai

TNTs Mediate Senescence in MSC Spheroids

Previous studies from the labs of J.

Challenges for MSCs in the Clinic

The realization that mesenchymal stem cells (MSCs) play tissue supportive functions has prompted an increasing number of studies in a variety of clinical indications, thereby revealing additional challenges.

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