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Mesenchymal Stem Cells

Antibacterial Activity of Human MSCs

A new study led by researchers from the lab of Steven Dow (Colorado State University, Fort Collins, Colorado, USA) recently reported the antimicr

MFAT vs. BMAC: Mesenchymal Stem Cell Therapy Showdown for Osteoarthritis Treatment

A study compares the ability of intra‐articular injections of MSCs to provide pain and functional improvements in symptomatic knee osteoarthritis patients

Tunable Hydrogels for Mesenchymal Stem Cell Delivery

Stem cell therapies hold considerable promise, but their clinical application requires the development of appropriate delivery platforms; this includes synthetic hydrogels engineered to display fibrin‐like and other cell‐binding sites that promote cell adhesion and direct stem cell function and fate through “outside-in” signaling mechanisms.

MSC Mechanisms Improve ASO Distribution in HD

Antisense oligonucleotides (ASOs) represent promising therapeutic strategies for the suppression of toxic protein production in neurogenetic diseases, especially in Huntington's disease (HD); however, the pattern and mechanism of distribution of ASOs in the brain remain unclear.

Nucleoskeletal Regulation of MSC Differentiation

Nuclear morphology contributes to chromatin organization and gene expression, and now, researchers from the laboratory of Janet Rubin (University of No

MSC-EVS in ARDS - A Concise Review

A new STEM CELLS Translational Medicine review article discusses preclinical studie

Enhancing Bone Regeneration by Silencing Smurf1 in MSCs

The associated detrimental effects of the administration of high doses of bone morphogenetic proteins (BMPs) required to promote osteogenesis in orthopedic applications currently hinders many clinical applications.

Stem Cell Therapy in Idiopathic Pulmonary Fibrosis

A recent first‐in‐human clinical trial led by Vladimir Baklaushev (Federal Research Clinical Center FMBA of Russia, Moscow, Russi

The Fate of Adipose-Derived Mesenchymal Stem Cells

While the exogenous administration of adipose‐derived mesenchymal stromal cells (ASCs) holds great promise as a treatment strategy for wound healing by promoting tissue repair and regeneration, the best route of administration remains undefined.

PCK2 Promotes Osteogenesis by MSCs via Autophagy

The degradation products from autophagy can serve as an optional nutrient supply for cell survival and differentiation, making autophagy a suitable energy‐refueling process during osteogenesis by mesenchymal stem cells (MSCs).

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