Mesenchymal Stem Cells

A new study led by researchers from the lab of Steven Dow (Colorado State University, Fort Collins, Colorado, USA) recently reported the antimicr

A study compares the ability of intra‐articular injections of MSCs to provide pain and functional improvements in symptomatic knee osteoarthritis patients

Stem cell therapies hold considerable promise, but their clinical application requires the development of appropriate delivery platforms; this includes synthetic hydrogels engineered to display fibrin‐like and other cell‐binding sites that promote cell adhesion and direct stem cell function and fate through “outside-in” signaling mechanisms.

Antisense oligonucleotides (ASOs) represent promising therapeutic strategies for the suppression of toxic protein production in neurogenetic diseases, especially in Huntington's disease (HD); however, the pattern and mechanism of distribution of ASOs in the brain remain unclear.

Nuclear morphology contributes to chromatin organization and gene expression, and now, researchers from the laboratory of Janet Rubin (University of No

A new STEM CELLS Translational Medicine review article discusses preclinical studie

The associated detrimental effects of the administration of high doses of bone morphogenetic proteins (BMPs) required to promote osteogenesis in orthopedic applications currently hinders many clinical applications.

A recent first‐in‐human clinical trial led by Vladimir Baklaushev (Federal Research Clinical Center FMBA of Russia, Moscow, Russi

While the exogenous administration of adipose‐derived mesenchymal stromal cells (ASCs) holds great promise as a treatment strategy for wound healing by promoting tissue repair and regeneration, the best route of administration remains undefined.

The degradation products from autophagy can serve as an optional nutrient supply for cell survival and differentiation, making autophagy a suitable energy‐refueling process during osteogenesis by mesenchymal stem cells (MSCs).