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Mesenchymal Stem Cells

CD146-sorted Mesenchymal Stem Cells Provide for Enhanced Therapeutic Outcomes

Homogenous populations of perivascular-like MSCs might exhibit more robust responses to inflammatory insult and provide a more “powerful” therapeutic approach

Mechanically Activated EV-based Osteogenesis

Osteocyte‐derived mechanically-activated extracellular vesicles hold great potential as a novel cell‐free therapy to enhance bone regeneration

Functional Markers for MSC Therapy in Osteoarthritis

MSC chondrogenesis represents a transient property lost as cells age in vitro, whereas trophic repair potency is maintained until MSCs cease to grow. 

Alternative Splicing in MSC Differentiation

A new review article in STEM CELLS discusses the underrated role of alternative splicing, a process that produces multiple similar but functionally distinct proteins from one gene, in MSC differentiation

MSC Therapy for cGvHD

Mesenchymal stem cell (MSC) therapy represents a promising option for the treatment of steroid‐refractory chronic graft‐vs‐host disease (cGvHD); however, we lack clinical trial data, and the mechanisms of action remain unknown.

Mesenchymal Stem Cells as Neural Therapeutics

A concise review article published recently in STEM CELLS Translational Medicine from Marcin Majka and Bogna Badyra (Jagiellonian University Medical College, Cracow, Poland)

MSC Secreted Factors – The New Player in the Battle Against Antibiotic-Resistant Bacteria

New research shows how MSC-secreted factors can impair biofilm formation by cutaneous wound‐related bacteria and disrupt mature biofilms via a protease‐dependent mechanism

Reviewing Glioblastoma-Mesenchymal Stem Cell Interactions

The unique properties of mesenchymal stem cells (MSCs) have made them an exciting resource for the treatment of a range of human conditions, including degenerative and inflammatory diseases, tissue damage, and cancer.

Magnetic Guidance Improves MSC Therapy

Although the systemic administration of mesenchymal stem cells (MSCs) ameliorates lung inflammation and attenuates fibrosis in experimental silicosis, MSC therapy fails to reverse collagen deposition and granuloma formation.

Notch and BMP-mediated Osteoblastogenesis

Stimulation via the canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMP) can induce the osteoblastic differentiation of bone-marrow-derived human mesenchymal stem cells (hMSC); however, the question as to how these two pathways lead to the same phenotypic outcome remains unanswered.

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