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Neural Stem Cells

Endogenous Stem Cell Response After SCI

Emerging evidence suggests that many components of the secondary injury cascade following spinal cord injury (SCI), generally viewed as deleterious to host neuronal and glial cells, may trigger the activation of endogenous ependymal neural stem/progenitor cells (NSPCs).

Promoting Neurogenesis After Spinal Cord Injury

The myelin‐associated inhibitory microenvironment existing after spinal cord injury (SCI) blocks nerve regeneration; however, new research from the lab of Jianwu Dai

Neonatal Astrocyte-derived Factor Boosts NSC-mediated Repair after Traumatic Brain Injury

Neonatal astrocytes, but not adult astrocytes, promote neural stem cell proliferation and the repair of brain injury via high expression of Tenascin‐C

T cell Infiltration into the Neurogenic Niche Linked to Age-related Decline in Brain Function

New research establishes a link between the functional decline of the neurogenic niche in the aging mouse subventricular zone and immune cell infiltration

Stem Cell-Derived EV Protects the Irradiated Brain

Cranial radiation therapy as a treatment of brain cancers can lead to adverse impacts on cognitive function; however, previous studies from the laboratory of Charles L. Limoli (University of California, Irvine, USA) discovered that human neural stem cells (hNSCs) can provide beneficial neurocognitive effects in the irradiated brain.

Resistance of Neural Stem Cells to Chemo‐Radiation Therapy

Standard of care therapy for aggressive glioblastoma consists of safe maximum resection, concurrent temozolomide and X‐irradiation followed by adjuvant temozolomide therapy; however, we do not understand if this treatment approach affects adult neurogenesis in the ventricular‐subventricular zone (V‐SVZ) of the mammalian brain.

Single-Cell Probing of Neural Progenitors

Clonal analysis in histology and single-cell transcriptomics have shed new light on our understanding of forebrain germinal activity at pre‐ and post‐natal time points.

Herpes Simplex Virus Impairs Adult Neurogenesis

A new study from the labs of Roberto Piacentini and Claudio Grass

CD71 as a Negative Selection Marker for Neurons

A recent STEM CELLS study from the lab of Jan Pruszak (University of Freiburg, Freiburg, Germany) describes an exhaustive characterization of neural cell types by surface antigens, exploiting human pluripotent stem cell‐derived neural cell syste

Study Highlights the Role of Migratory Neural Progenitor Cells in Prostate Cancer Development

NPCs migrate through the blood to target primary tumors or metastatic tissues where the initiate neurogenesis and support the development of prostate cancer


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