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Neural Stem Cells

Transsynaptic Tracing to Assess Grafted Neural Circuits

Monosynaptic tracing has accelerated the pace and depth of studies into the connectivity between stem cell‐derived grafts and the host nervous system, revealing that transplant‐derived neurons receive anatomically‐appropriate inputs when transplanted into pre‐clinical animal models. However, studies have yet to address whether those inputs are critical to functional recovery.

GPCR-mediated Cerebral Organoid Formation

In a recent STEM CELLS study, researchers from the lab of Gang Pei (University of Chinese Academ

Proteasome Identified as the Mechanistic Link between Exercise and Neurogenesis

New study suggests that exercise enhances hippocampal IGF‐1 signaling, which enhances neurogenesis through an Nrf2‐mediated increase in  proteasome activity

miRNAs Regulates hNSC Fate Via the Mitochondrion

A recent STEM CELLS article from researchers led by Yogita K.

Mouse Study Describes Novel Therapeutic Targets for Spinal Cord Injury Treatment

New findings highlight a significant role for an EGFR‐ERK-TRIM32 axis as a controlling mechanism behind nerve regeneration after spinal cord injury

Visualization of Undifferentiated Neural Stem/Progenitor Cells

Stem cell‐based therapy using neural stem/progenitor cells (NS/PCs) derived from human‐induced pluripotent cells (hiPSCs) represents a promising approach for the treatment of neurodegenerative diseases and neurotrauma.

Co-stimulation Blockade Promotes Allogenic Stem Cell Therapy for Dysmyelination Disorders

A short-term co-stimulation blockade to modulate T-cell activation allows for the engraftment of glial-restricted progenitor allografts in the mouse central nervous system

Subpial Stem Cell Grafting in Immunodeficient Rats

A new article from the lab of Martin Marsala (University of California, San Diego, La Jolla, CA, USA) describes a novel subpial spinal cell delivery tech

Wnt5a-mediated Regulation of Adult-born Hippocampal Neurons

A new study led by Lorena Varela‐Nallar (Universidad Andres Bello, Santiago, Chile) recently established Wnt5a as a neurogenic factor that pro

HSV-1 Induced Amyloid Beta-accumulation in NSCs Reduces Adult Neurogenesis

A new study investigates the influence of HSV‐1 infection and Aβ accumulation on adult hippocampal neurogenesis by studying neural stem cells in vitro and in vivo


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