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Neural Stem Cells

Visualization of Undifferentiated Neural Stem/Progenitor Cells

Stem cell‐based therapy using neural stem/progenitor cells (NS/PCs) derived from human‐induced pluripotent cells (hiPSCs) represents a promising approach for the treatment of neurodegenerative diseases and neurotrauma.

Co-stimulation Blockade Promotes Allogenic Stem Cell Therapy for Dysmyelination Disorders

A short-term co-stimulation blockade to modulate T-cell activation allows for the engraftment of glial-restricted progenitor allografts in the mouse central nervous system

Subpial Stem Cell Grafting in Immunodeficient Rats

A new article from the lab of Martin Marsala (University of California, San Diego, La Jolla, CA, USA) describes a novel subpial spinal cell delivery tech

Wnt5a-mediated Regulation of Adult-born Hippocampal Neurons

A new study led by Lorena Varela‐Nallar (Universidad Andres Bello, Santiago, Chile) recently established Wnt5a as a neurogenic factor that pro

HSV-1 Induced Amyloid Beta-accumulation in NSCs Reduces Adult Neurogenesis

A new study investigates the influence of HSV‐1 infection and Aβ accumulation on adult hippocampal neurogenesis by studying neural stem cells in vitro and in vivo

Endogenous Stem Cell Response After SCI

Emerging evidence suggests that many components of the secondary injury cascade following spinal cord injury (SCI), generally viewed as deleterious to host neuronal and glial cells, may trigger the activation of endogenous ependymal neural stem/progenitor cells (NSPCs).

Promoting Neurogenesis After Spinal Cord Injury

The myelin‐associated inhibitory microenvironment existing after spinal cord injury (SCI) blocks nerve regeneration; however, new research from the lab of Jianwu Dai

Neonatal Astrocyte-derived Factor Boosts NSC-mediated Repair after Traumatic Brain Injury

Neonatal astrocytes, but not adult astrocytes, promote neural stem cell proliferation and the repair of brain injury via high expression of Tenascin‐C

T cell Infiltration into the Neurogenic Niche Linked to Age-related Decline in Brain Function

New research establishes a link between the functional decline of the neurogenic niche in the aging mouse subventricular zone and immune cell infiltration

Stem Cell-Derived EV Protects the Irradiated Brain

Cranial radiation therapy as a treatment of brain cancers can lead to adverse impacts on cognitive function; however, previous studies from the laboratory of Charles L. Limoli (University of California, Irvine, USA) discovered that human neural stem cells (hNSCs) can provide beneficial neurocognitive effects in the irradiated brain.

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