Adipose Stem Cells

A recent STEM CELLS Translational Medicine study led by Lei Liu (Sichuan University, Chengdu, Sichuan, China) recently described a novel long noncoding (lnc)RNA (lncRNA‐Adi) highly expressed in adipogenic‐induced adipose-derived mesenchymal stem cells (ASCs).

Fibroblast growth factor 2 promotes the initial expansion of ASCs through a STAT3‐dependent response, although continuous exposure limits their long‐term proliferation

The expansion of human adipose‐derived stem/stromal cells (hASCs) typically takes place in serum‐containing media, and a recent study led by Louis Casteilla,

The in vitro expansion of mesenchymal stem cells leads to a decrease in their proliferative and therapeutic capacity, making basic research on factors regulating proliferation of fundamental importance for their successful translation into clinical applications.

Researchers track the fate of adipose-derived MSCs to establish that both systemic and local administration routes permitted significantly enhanced wound repair

Bone regrowth may be achieved using different biomaterial scaffolds that provide structural and biological cues to stem cells to stimulate osteogenic differentiation. Furthermore, new knowledge regarding the mechanisms of bone repair is of paramount importance to address the significant steps required for precise translational medicine to treat patients.

Adipose‐derived mesenchymal stem cells (ASCs) are a valuable cell source for regenerative medicine, and prolonged in vitro cell expansion may be required to develop ASC‐based products.

Radiation therapy stimulates progressive and pathological soft tissue fibrosis, which distorts tissue form and negatively influences function. Researchers from the lab of Derrick C.

New research suggests that CCR7-overexpressing human ASCs possess a greater immunomodulatory capacity and enhance the survival of vascularized composite allotransplants

The tissue stromal vascular fraction of adipose tissue, a heterogeneous cell population containing adipose‐derived stem cells, has been successfully applied in translational studies and clinical trials.