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Adipose Stem Cells

Scaffold-boosted ASC-mediated Bone Regrowth

Bone regrowth may be achieved using different biomaterial scaffolds that provide structural and biological cues to stem cells to stimulate osteogenic differentiation. Furthermore, new knowledge regarding the mechanisms of bone repair is of paramount importance to address the significant steps required for precise translational medicine to treat patients.

FGF2 Alters the Aging of Human ASCs

Adipose‐derived mesenchymal stem cells (ASCs) are a valuable cell source for regenerative medicine, and prolonged in vitro cell expansion may be required to develop ASC‐based products.

Fat Grafting Rescues Radiation-induced Limb Contracture

Radiation therapy stimulates progressive and pathological soft tissue fibrosis, which distorts tissue form and negatively influences function. Researchers from the lab of Derrick C.

Secondary Lymphoid Organ-targeted ASCs Improve Tissue Grafts via Enhanced Immunomodulation

New research suggests that CCR7-overexpressing human ASCs possess a greater immunomodulatory capacity and enhance the survival of vascularized composite allotransplants

Collagenase-free Methods for Tissue SVF Isolation

The tissue stromal vascular fraction of adipose tissue, a heterogeneous cell population containing adipose‐derived stem cells, has been successfully applied in translational studies and clinical trials.

MSC Properties Rely on Tissue of Origin

Researchers led by Karin Tarte (Université de Rennes, France) recently assessed the influence of tissue of origin on the functional properties of mesenchymal stem cells (MSCs) in a recent STEM CELLS study. Ménard et al.

Immunoregulatory Role of hASC-CCR7 in VCA

A new study from the laboratories of Yan Han and Hong Li (First Medical Centre of Chinese PLA General Hospital, Beijing, People's Republic of China) recently explored the utility of Chemokine receptor 7 (CCR7) overexpression in human adipose-derived stem cells (hASCs) as a means to induce immune intolerance following vascularized composite allotransplantation (VCA).

Reviewing Adipose Stem Cells and Cancer

The interaction of cancer cells with the multitude of other cell types present within the tumor microenvironment plays a crucial role in cancer development and progression.

ASCs Restore Bone Regeneration After Infection

Previous research from the lab of Björn Behr (University Hospital Bergmannsheil Bochu

Single MSC Injection Provides Functional improvements and Pain Relief for Knee Osteoarthritis Patients

Trial of intra‐articular injections of autologous adipose-derived MSCs in patients with knee osteoarthritis provides proof of functional improvement and pain relief

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